ArticleeNeuro2025
A Preclinical Alcohol Biobank: Samples from Behaviorally Characterized HS Rats for AUD Research.
Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Ivermectin reduces withdrawal-induced alcohol intake in rats: Association with CeA GABAergic enhancement and P2rx4 genetic liability.Neuropharmacology · 2026Article
- High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake.Psychopharmacology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Alcohol use disorder (AUD) imposes a significant global health burden, yet effective treatments remain limited. There are no well-characterized, AUD-relevant, rodent biological sample repositories to support research in this area. To address this gap, we established the Alcohol Biobank, a comprehensive resource containing thousands of samples from over 700 (half males, half females) genetically diverse heterogeneous stock (HS) rats. Modeled after two successful cocaine and oxycodone biobanks, this repository uses the chronic intermittent ethanol vapor exposure (CIE) model, paired with oral self-administration, to characterize AUD-like behaviors, including ethanol consumption, preference, motivation, and withdrawal symptoms such as allodynia and anxiety-like behavior. Longitudinal samples (blood, urine, and feces) are collected before, during, and after ethanol exposure, while tissue samples (brain, heart, kidneys, liver, cecum, reproductive organs, adrenal glands, blood) are obtained at intoxication, acute withdrawal, protracted abstinence, or from naive controls. Samples are preserved via snap-freezing or paraformaldehyde fixation to support diverse applications, including genomics, transcriptomics, proteomics, and neuroanatomy. Samples are freely available to nonprofit organizations at www.alcoholbiobank.org Genetic and behavioral data about these rats are deposited in public repositories. The Alcohol Biobank facilitates collaborative research to uncover biomarkers and develop novel therapies for AUD, addressing a critical need in addiction science.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.