Evidence map›Paper›PMID 40940321›Full record

ArticleScientific reports2025

Label-free volumetric imaging of porcine kidney tissue over extended areas using dynamic MHz-OCT.

Sazgar Burhan, Madita Göb, Mario Pieper, Tjalfe Laedtke, Thorge Grahl, Michael Münter, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, Peter König, Robert Huber

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sazgar Burhan *Institute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.ORCID http://orcid.org/0009-0004-4135-1197
Madita Göb *Institute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0002-5992-9274
Mario PieperInstitute of Anatomy, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0003-2589-6782
Tjalfe LaedtkeInstitute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.
Thorge GrahlInstitute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.
Michael MünterMedizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0002-8004-3646
Hinnerk Schulz-HildebrandtInstitute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0003-4389-9151
Gereon HüttmannInstitute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0002-5051-3037
Peter KönigInstitute of Anatomy, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Robert HuberInstitute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562, Lübeck, Germany. robert.huber@uni-luebeck.de.ORCID http://orcid.org/0000-0001-9785-6574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic optical coherence tomography (dOCT) enables high-resolution, label-free 3D tissue imaging with functional contrast, offering a potential advancement in kidney transplant viability assessment. Currently, no widely accepted non-invasive method provides an objective evaluation of transplant viability, as conventional imaging lacks the resolution to assess microvascular integrity and cellular dynamics. However, the clinical use of available dOCT systems is limited by prolonged imaging times that hinder clear visualization of tissue dynamics. To address these challenges, this paper presents a swept-source 3.2 MHz-OCT system for dynamic, high-speed, extended-area imaging. The system integrates an optimized inter-volume scan protocol and a micrometer-precision linear robot, enabling extended‑scale tissue imaging over an area of about 2.6 × 2.6 mm

Indexed as

Imaging, Three-DimensionalKidneyTomography, Optical CoherenceAnimalsKidney TransplantationSwine

Identifiers

PMID40940321
PMCPMC12432236

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.