ArticleNature plants2025
Gene body methylation regulates gene expression and mediates phenotypic diversity in natural Arabidopsis populations.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mapping genetic modifiers of epimutation rates identifies VIM2/4 as dosage-sensitive negative regulators of CG methylation maintenance.Nature plants · 2026Article
- A dual genome-methylome map of clonal evolution in grapevine.Genome biology · 2026Article
- Integration of DNA methylation and gene expression analysis in Gephyrocapsa huxleyi provides insight into genes related to calcification.G3 (Bethesda, Md.) · 2026Article
- SOPA and SIMPA: normalized single-sample integrated multiomics pathway analysis of tumor heterogeneity in solid cancers.Briefings in bioinformatics · 2026Article
- siRNA-guided DNA-methylation at a sucrose transporter gene potentially contributes to climatic plant adaptation.PLoS biology · 2026Article
- Article
- Heterochromatin reorganization associated with the transcriptional reprogramming under viral infection in Arabidopsis.Nucleic acids research · 2026Article
- Inheritable Epigenetic Memory Induced by Parental Salt Stress Influences Transgenerational Plasticity ofEcology and evolution · 2026Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Calm in the midst of the storm: inferring gene expression stability in flowering plants.Frontiers in plant science · 2026Article
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.Environmental epigenetics · 2026Article
- Adaptation beyond the DNA sequence.Nature plants · 2025Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Genetic variation is generally regarded as a prerequisite for evolution. In principle, epigenetic information inherited independently of DNA sequence can also enable evolution, but whether this occurs in natural populations is unknown. Here we show that single-nucleotide and epigenetic gene body DNA methylation (gbM) polymorphisms explain comparable amounts of expression variance in Arabidopsis thaliana populations. We genetically demonstrate that gbM regulates transcription, and we identify and genetically validate many associations between gbM polymorphism and the variation of complex traits: fitness under heat and drought, flowering time and accumulation of diverse minerals. Epigenome-wide association studies pinpoint trait-relevant genes with greater precision than genetic association analyses, probably due to reduced linkage disequilibrium between gbM variants. Finally, we identify numerous associations between gbM epialleles and diverse environmental conditions in native habitats, suggesting that gbM facilitates adaptation. Overall, our results indicate that epigenetic methylation variation fundamentally shapes phenotypic diversity in a natural population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.