Evidence map›Paper›PMID 40940550›Full record

ArticleJournal of neurology2025

Amygdala-predominant Lewy bodies associate with cognitive decline and amygdala atrophy in Alzheimer's disease neuropathological change.

Francisco C Almeida, Alexandra Santos, Tiago Jesus, Kathryn Gauthreaux, Charles N Mock, Walter A Kukull, John F Crary, Tiago Gil Oliveira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Deep learning-based MRI analysis reveals Lewy body co-pathology accelerates brain aging in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Where do PDD and DLB SYNdromes fit in neuronal alpha-SYNuclein biological frameworks?Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francisco C AlmeidaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal. franciscoalmeida.neurorradiologia@chporto.min-saude.pt.ORCID http://orcid.org/0000-0002-8404-4136
Alexandra SantosLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal.
Tiago JesusLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal.
Kathryn GauthreauxDepartment of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
Charles N MockDepartment of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
Walter A KukullDepartment of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
John F CraryFriedman Brain Institute, Departments of Pathology, Neuroscience, and Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tiago Gil OliveiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal. tiago@med.uminho.pt.

Funding

National Alzheimer's Coordinating CenterU24AG072122 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$9.3M
NIA NIH HHS U24 AG072122NIH HHS AG016976NIH HHS AG072122
6 · The paper itself

Abstract

introductionAmygdala-predominant Lewy body (LB) pathology occurs frequently in association with advanced Alzheimer's disease (AD). Its clinical significance is not yet fully clarified. We investigated the influence of amygdala-predominant LB in cognitive profiles and brain atrophy in the context of AD neuropathological change (ADNC).

methodsWe performed a retrospective cohort study from the National Alzheimer's Coordinating Center dataset assessing the influence of amygdala-predominant LB and caudo-rostral LB stages in longitudinal neuropsychological and cognitive testing, as well as on regional brain volume in cross-sectional MRI.

resultsAmygdala-predominant LB associated with specific deficits in neuropsychological testing compared with those without LB and with limbic LB (p ≤ 0.05). This was accompanied by focal atrophy of the right amygdala compared with those without LB co-pathology (p ≈ 0.02), although this result did not survive false discovery rate correction. DISCUSSION: These results suggest that amygdala-predominant LB is an important form of co-pathology in ADNC, associating with cognitive decline and focal brain atrophy.

Indexed as

Alzheimer DiseaseAmygdalaCognitive DysfunctionLewy BodiesAgedAged, 80 and overAtrophyCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeuropsychological TestsRetrospective StudiesAlzheimer’s diseaseAmygdalaCo-pathologyLewy bodiesMRI

Identifiers

PMID40940550
PMCPMC13167139

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.