Evidence map›Paper›PMID 40940651›Full record

ArticleAutism research : official journal of the International Society for Autism Research2025

Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.

Alejandra Fernandez, Nick Sarn, Charis Eng, Kevin M Wright

Abstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alejandra FernandezVollum Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-5489-5300
Nick SarnGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Charis EngGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kevin M WrightVollum Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0001-5094-5270

Funding

The role of dystroglycan in neural circuit development.R01NS091027 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI WRIGHT, KEVIN · 2016 to 2020
$1.9M
The role of Pten on primary sensory neuron developmentK01NS116168 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI FERNANDEZ, ALEJANDRA · 2020 to 2022
$294k
Collins Medical TrustNIH HHS K01NS116168NIH HHS R01NS091027NINDS NIH HHS K01 NS116168NINDS NIH HHS R01 NS091027OHSU Fellowship for Diversity in Research
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper- or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood. Recent studies in rodent models of ASD identified differences in dorsal root ganglia (DRG) neurons that convey somatosensory information to the central nervous system. However, it is unknown how ASD-associated alterations in DRG neurons emerge during development and if these phenotypes are conserved across ASD models. We examined Pten (phosphatase and tensin homolog) heterozygous mice (Pten

Indexed as

Autism Spectrum DisorderPTEN PhosphohydrolaseAnimalsDisease Models, AnimalFemaleGanglia, SpinalHeterozygoteMaleMiceNeurodevelopmentSensory Receptor CellsPTEN PhosphohydrolasePten protein, mouseautism Spectrum disorderDRGneuronal differentiationPTENsomatosensory

Identifiers

PMID40940651
PMCPMC12661289

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.