Evidence map›Paper›PMID 40940763›Full record

ArticleCells2025

Targeting Diabetic Retinopathy with Human iPSC-Derived Vascular Reparative Cells in a Type 2 Diabetes Model.

Sergio Li Calzi, Dibyendu Chakraborty, Ping Hu, Ram Prasad, Yvonne Adu-Rutledge, Cristiano Vieira, Fadeela Sheini, Michael E Boulton, Mervin C Yoder, Changde Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Autophagy in ocular diseases: from mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sergio Li CalziDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0001-8963-1519
Dibyendu ChakrabortyDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0003-3934-3249
Ping HuDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Ram PrasadDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-1931-5040
Yvonne Adu-RutledgeDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0003-3899-7064
Cristiano VieiraDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Fadeela SheiniDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Michael E BoultonDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-0796-1766
Mervin C YoderDepartment of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Changde ChengDepartment of Hematology & Oncology, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.

Funding

NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
LXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2M
Correction of diabetic retinopathy by mitochondrial transferR01EY034133 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Maria Bartolomeo Grant, DENIS A PROSHLYAKOV · 2023 to 2026
$2.2M
Brain-gut-retina axis in diabetic retinopathyR01EY033620 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHARLES J FRAZIER, Maria Bartolomeo Grant · 2023 to 2026
$2.1M
Somatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9M
ACE2 on gut barrier dysfunction and BRB disruptionR01EY032753 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Edwin Boulton, Maria Bartolomeo Grant · 2022 to 2026
$1.8M
ACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6M
NEI NIH HHS R01 EY012601NEI NIH HHS R01EY012601, R01EY028858, R01EY028037, R01EY025383, R01EY032753, R01EY033620, and R01EY034133NEI NIH HHS R01 EY025383NEI NIH HHS R01 EY028037NEI NIH HHS R01 EY028858NEI NIH HHS R01 EY032753NEI NIH HHS R01 EY033620NEI NIH HHS R01 EY034133
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyInduced Pluripotent Stem CellsAnimalsAntigens, CD34Disease Models, AnimalElectroretinographyEndothelial CellsHumansMaleMiceRetinaTomography, Optical CoherenceAntigens, CD34CD34 cellsdiabetic retinopathyendothelial colony forming cellsinducible pluripotent stem cellsKNA cellsvascular repair

Identifiers

PMID40940763
PMCPMC12428381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.