Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Thomas N O'ConnorGenetics and Genomics Graduate Program, Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0001-6965-0704
Nan ZhaoDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Haley M OrciuoliDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sundeep MalikDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Alice BrasileCenter for Advanced Studies and Technology (CAST), University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0009-0002-5927-6995
Laura PietrangeloCenter for Advanced Studies and Technology (CAST), University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0003-1197-7813
Miao HeDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Linda GroomDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jennifer LeighDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Zahra MahamedDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Chen LiangDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-5562-350X
Feliciano ProtasiCenter for Advanced Studies and Technology (CAST), University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Robert T DirksenDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-3182-1755
Funding
Pathophysiology of Tubular Aggregate MyopathyR01AR086382 · NIAMS · UNIVERSITY OF ROCHESTER · PI DIRKSEN, ROBERT T · 2025 to 2025
$1.7M
National Institute of Health AR086382NIAMS NIH HHS R01 AR086382NIH MDA 956014Telethon ONLUS GGP19231
6 · The paper itself
Abstract
Tubular aggregate myopathy (TAM) is an inherited skeletal muscle disease associated with progressive muscle weakness, cramps, and myalgia. Tubular aggregates (TAs) are regular arrays of highly ordered and densely packed straight-tubules observed in muscle biopsies; the extensive presence of TAs represent a key histopathological hallmark of this disease in TAM patients. TAM is caused by gain-of-function mutations in proteins that coordinate store-operated Ca
Indexed as
Gain of Function MutationMyopathies, Structural, CongenitalORAI1 ProteinPhysical Conditioning, AnimalAnimalsCalciumDisease Models, AnimalMaleMiceMuscle, SkeletalSarcoplasmic ReticulumStromal Interaction Molecule 1CalciumORAI1 ProteinOrai1 protein, mouseStromal Interaction Molecule 1aggregateexercisemitochondriamyopathyphysiologyproteomicssarcoplasmic reticulumskeletal muscle
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Voluntary Wheel Running Mitigates Disease in an Orai1 Gain-of-Function Mouse Model of Tubular Aggregate Myopathy. · full record | Socratic