Evidence mapPaperPMID 40940801Full record

ReviewCells2025

Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications.

Huan-Yu Zhao, Jie-Bing Jiang, Shu-Na Wang, Chao-Yu Miao

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huan-Yu ZhaoDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Jie-Bing JiangDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Shu-Na WangDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Chao-Yu MiaoDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.ORCID 0000-0002-8176-3434

Funding

National Natural Science Foundation of China Young Program 82304485
6 · The paper itself

Abstract

Cardiogenesis and heart cell composition and function constitute fundamental areas of cardiovascular medicine research, and exploring their underlying mechanisms is closely tied to the goals of precision medicine. This review comprehensively examines the composition and functions of the heart from embryonic organogenesis to maturity, and highlights the main breakthroughs of treatment strategies associated with these processes. By elaborating on the spatiotemporally specific signaling pathways and transcriptional networks that drive heart organogenesis and progenitor cell fate determination during the pivotal stages of cardiac development, and by systematically presenting the molecular biomarkers and functional characteristics of the principal cell types in mature heart, the latest advancements in related applications are summarized, with a particular emphasis on breakthroughs in gene/cell therapy, organoid development, and tissue engineering and regenerative medicine. This paper provides a theoretical foundation for precision interventions and regenerative medicine in cardiovascular disease using an axis that integrates cardiogenesis, cellular architecture, and therapeutic translation.

Indexed as

HeartOrganogenesisAnimalsCell DifferentiationHumansMyocardiumRegenerative MedicineSignal TransductionStem CellsTissue Engineeringcardiac organoidcardiogenesiscell therapygene therapymyocardial cell functionregenerative medicinetissue engineering

Identifiers

PMID40940801
PMCPMC12428614

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.