Evidence map›Paper›PMID 40940806›Full record

ArticleCells2025

Development and Characterization of a Novel Lineage of Renal Progenitor Cells for Potential Use in Feline Chronic Kidney Disease: A Preliminary Study.

Lara Carolina Mario, Juliana de Paula Nhanharelli, Jéssica Borghesi, Rafaela Rodrigues Ribeiro, Hianka Jasmyne Costa de Carvalho, Thamires Santos da Silva, Mariano Del Sol, Rodrigo da Silva Nunes Barreto, Sandra Maria Barbalho, Maria Angelica Miglino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lara Carolina MarioDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.
Juliana de Paula NhanharelliDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.
Jéssica BorghesiDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.
Rafaela Rodrigues RibeiroDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.
Hianka Jasmyne Costa de CarvalhoDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.ORCID 0000-0001-8733-4932
Thamires Santos da SilvaDepartment of Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.ORCID 0000-0002-7848-8558
Mariano Del SolCenter of Excellence in Morphological and Surgical Studies (CEMyQ), Universidad de La Frontera, Temuco 1145, Chile.ORCID 0000-0003-3686-6757
Rodrigo da Silva Nunes BarretoDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista (UNESP), Jaboticabal 14884-900, SP, Brazil.ORCID 0000-0001-5240-6959
Sandra Maria BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.ORCID 0000-0002-5035-876X
Maria Angelica MiglinoDepartment of Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.ORCID 0000-0003-4979-115X

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/05445-7
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a common and serious condition in felines. Accordingly, several cell therapies have been studied over the past decades for effective treatments. This study aimed to develop a new lineage of renal progenitor cells for use in cats with CKD. Metanephric and mesonephric progenitor cells were obtained from mesonephros and metanephros tissues of feline conceptuses at four distinct gestational stages. The cultured cells were characterized by their morphology, tumorigenic potential, immunophenotype determined by flow cytometry, and differentiation potential. We then conducted a pilot study in CKD-affected cats, comparing intraperitoneal injections of cultured metanephric progenitor cells (

Indexed as

Cat DiseasesCell LineageKidneyRenal Insufficiency, ChronicStem CellsAnimalsCatsCell DifferentiationCells, CulturedFemalePilot Projectscat healthcell therapychronic kidney diseasefelinefeline chronic kidney diseaserenal progenitor cells

Identifiers

PMID40940806
PMCPMC12427712

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.