Evidence map›Paper›PMID 40940848›Full record

ArticleCancers2025

Efficacy of Electrochemotherapy with Bleomycin, Oxaliplatin, or Oxaliplatin with Bevacizumab in the Treatment of Colorectal Hepatic Metastases in Rats.

Antonios E Spiliotis, Orestis Mallis Kyriakides, Sebastian Holländer, Gudrun Wagenpfeil, Matthias W Laschke, Matthias Glanemann, Gereon Gäbelein

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonios E SpiliotisDepartment of Surgery, Campus Charité Mitte, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-5947-3588
Orestis Mallis KyriakidesDepartment of Cardiovascular Surgery, Heart Center Niederrhein, Helios Hospital Krefeld, 47805 Krefeld, Germany.
Sebastian HolländerDepartment of General Surgery, Vascular-, Visceral- and Pediatric Surgery, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-6867-4234
Gudrun WagenpfeilInstitute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-1133-2049
Matthias W LaschkeInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421 Homburg, Germany.ORCID 0000-0002-7847-8456
Matthias GlanemannDepartment of General Surgery, Vascular-, Visceral- and Pediatric Surgery, Saarland University Medical Center, 66421 Homburg, Germany.
Gereon GäbeleinDepartment of General Surgery, Vascular-, Visceral- and Pediatric Surgery, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-9248-9717

Funding

Homburg Research Funding Program HOMFOR 2020
6 · The paper itself

Abstract

BACKGROUND/

objectivesElectrochemotherapy (ECT) has been shown to be effective in treating colorectal liver metastases when combined with bleomycin (BLM). Based on this promising finding, we compared in this study the efficacy of BLM with oxaliplatin (OXP) and bevacizumab (BVZ) in ECT.

methodsWAG/Rij rats were randomized into three groups and underwent ECT with intravenous injection of BLM, OXP, or OXP with BVZ for eight days following hepatic tumor cell implantation. Ultrasound and photoacoustic imaging served to assess oxygen saturation (SO

resultsBLM treatment significantly reduced SO

Indexed as

bevacizumabbleomycincolorectal cancerElectrochemotherapyoxaliplatin

Identifiers

PMID40940848
PMCPMC12427181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.