ArticleCancers2025
IL-1α Promotes Cancer Cell Migration and Is a Potential Prognostic Marker in Oral Squamous Cell Carcinoma.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesInterleukin-1 alpha (IL-1α) has been linked to tumor progression in various cancer types; however, its role in oral cancer pathogenesis remains largely unexplored. This study aimed to investigate the clinical significance of IL-1α expression in oral squamous cell carcinoma (OSCC), with a specific focus on its role in modulating cancer cell phenotype.
methodsPrimary OSCC tissue specimens were collected from 104 patients and subjected to immunohistochemical analysis to assess IL-1α expression. OSCC cell lines were cultured for functional assays, and their protein and mRNA expressions were verified using western blotting and real-time polymerase chain reaction, respectively. The effects of IL-1α expression on OSCC cell proliferation, migration, and gene expression were subsequently examined.
resultsIL-1α expression varied among OSCC tissues and cell lines both in vivo and in vitro. Notably, siRNA-mediated suppression of IL-1α in HSC3 cells impaired migration while leaving proliferation unaffected, highlighting its functional role in promoting cancer cell motility.
conclusionsOur in vivo and in vitro findings revealed varied IL-1α expression in OSCC and its association with a motile phenotype, suggesting that case-specific IL-1α assessment could hold prognostic value in oral cancer.
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