Circulating T-Cell Receptor Excision Circles at Birth and Risk of Childhood Cancers.

Jun Tao, Paul S Albert, Nellie Gottlieb, Paige Miller, Eric A Engels

Abstract read

In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun TaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0003-2899-0248

Paul S AlbertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

Nellie GottliebCalifornia Cancer Reporting and Epidemiologic Surveillance (CalCARES) Program, University of California Davis Comprehensive Cancer Center, Sacramento, CA 95838, USA.

Paige MillerCancer Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX 78735, USA.ORCID 0009-0007-2327-5823

Eric A EngelsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

Funding

NCI NIH HHS Intramural Research Funding

6 · The paper itself

Abstract

backgroundT-cell receptor excision circles (TRECs) are measured in newborn screening programs in the United States to identify severe combined immunodeficiency (SCID). We hypothesized that relatively low TREC levels at birth, even within the normal range, could indicate compromised immunity and higher susceptibility to childhood cancers.

methodsWe conducted a case-control study using linked data from the newborn screening programs and cancer registries in California and Texas to examine the association between TREC levels and risk of childhood cancer. The study included 2196 cancer cases and 10,980 controls from California and 1186 cancer cases and 5890 controls from Texas.

resultsIn California, acute myeloid leukemia cases had significantly lower TREC levels compared with their matched controls (

conclusionsWe did not observe consistent associations between TREC levels at birth and childhood cancer risk. A possible explanation for the lack of more clear-cut differences in TREC levels between cases and matched controls might be the complex etiology of childhood cancers. The results underscore the need for longitudinal studies that incorporate additional immune biomarkers to understand the immunologic basis of childhood cancer development.

Indexed as

childhood cancerimmunodeficiencynewborn screeningpediatric cancerT-cell receptor excision circle

Identifiers

PMID40941000

DOI10.3390/cancers17172903

PMCPMC12428733

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.