Evidence map›Paper›PMID 40943120›Full record

ReviewInternational journal of molecular sciences2025

The Role of Selected Myokines in the Development of Cardiovascular Diseases, and Their Involvement in Developing Heart Failure in Rheumatoid Arthritis Patients.

Jakub Kuna, Grzegorz Chmielewski, Łukasz Jaśkiewicz, Michalina Knapik, Magdalena Krajewska-Włodarczyk

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jakub KunaDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.ORCID 0000-0002-4216-9731
Grzegorz ChmielewskiDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.ORCID 0000-0003-4498-7532
Łukasz JaśkiewiczDepartment of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, ul. Michała Oczapowskiego 2, 10-719 Olsztyn, Poland.ORCID 0000-0002-0035-4314
Michalina KnapikDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.ORCID 0009-0009-4746-6987
Magdalena Krajewska-WłodarczykDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.ORCID 0000-0002-7857-347X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases, which are among the most common diseases of the population and among the leading causes of death, are a constant topic of many research centers. A deeper understanding of their pathogenesis may contribute to the development of innovative diagnostic and therapeutic techniques. Recently, the role of myokines-a group of cytokines secreted mainly by muscle cells-has been increasingly emphasized in the development of these diseases. Both their excess and deficiency can cause undesirable effects that are involved in the pathomechanism of these diseases. In this review, we focus on the latest studies on the role of myonectin, irisin, musclin, follistatin-like1 (FSTL1), dermcidin, apelin, and myostatin in the pathogenesis of coronary artery disease, heart attack, heart failure, and hypertension. In particular, we look at myostatin and irisin in the context of the development of heart failure and decreased levels of apelin with higher cardiovascular risk in a group of patients with rheumatoid arthritis.

Indexed as

Arthritis, RheumatoidCardiovascular DiseasesCytokinesHeart FailureAnimalsApelinFibronectinsHumansMyokinesMyostatinApelinCytokinesFibronectinsFNDC5 protein, humanMyokinesMyostatinapelincoronary heart diseasedermcidinfollistatin-like1 (FSTL1)heart failurehypertensionirisinmusclinmyokinesmyonectinmyostatinrheumatoid arthritis

Identifiers

PMID40943120
PMCPMC12428051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.