Evidence map›Paper›PMID 40943138›Full record

ArticleInternational journal of molecular sciences2025

Comparative Analysis of Gene and MicroRNA Expression in Subcutaneous Adipose Tissue in Metabolically Healthy and Unhealthy Obesity.

Natalia O Markina, Georgy A Matveev, Ksenia A Zasypkina, Natalia V Khromova, Alina Yu Babenko, Evgeny V Shlyakhto

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia O MarkinaScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
Georgy A MatveevScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.ORCID 0000-0002-2695-4924
Ksenia A ZasypkinaScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.ORCID 0000-0002-9699-1210
Natalia V KhromovaScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
Alina Yu BabenkoScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.ORCID 0000-0002-0559-697X
Evgeny V ShlyakhtoScience Department of Metabolic Deviations and Personalized Prevention, Almazov National Medical Research Centre, St. Petersburg 197341, Russia.

Funding

The grant of the Science Foundation of the Russian Federation №25-75-30010 dated 22 may 2025
6 · The paper itself

Abstract

Metabolically healthy (MHO) and unhealthy obesity (MUO) exhibit distinct molecular genetic mechanisms underlying metabolic disorders. Studying gene and microRNA expression in subcutaneous adipose tissue (SAT) may reveal key pathogenetic differences between these phenotypes. We compared the expression of genes (ADIPOQ, HIF1A, CCL2) and microRNAs (miR-142-3p, miR-155, miR-378) in SAT between MHO and MUO patients and assessed their association with metabolic parameters. The study included 39 obese patients (19 MHO, 20 MUO) and 10 healthy controls. SAT biopsies were analyzed using real-time PCR. Correlations with clinical and metabolic markers were evaluated. Obese patients showed decreased ADIPOQ (

Indexed as

MicroRNAsObesitySubcutaneous FatAdiponectinAdultBiomarkersCase-Control StudiesChemokine CCL2FemaleGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedAdiponectinADIPOQ protein, humanBiomarkersCCL2 protein, humanChemokine CCL2HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsMIRN142 microRNA, humanMIRN155 microRNA, humanMIRN378 microRNA, humanadipose tissue hypoxiainsulin resistancemetabolically healthy obesitymicroRNAsubcutaneous adipose tissue

Identifiers

PMID40943138
PMCPMC12428018

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.