Evidence map›Paper›PMID 40943248›Full record

ArticleInternational journal of molecular sciences2025

Circulating ORM2 as a Biomarker of Metabolic Dysfunction: Evidence from the KADEM Study in Kuwaiti Adults.

Mohamed Abu-Farha, Ahmed N Albatineh, Bader Alawadh, Loulwa Alsalem, Irina Al-Khairi, Preethi Cherian, Fahad Al-Ajmi, Mohammad Qaddoumi, Muhammad Abdul-Ghani, Fahd Al-Mulla and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohamed Abu-FarhaDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.ORCID 0000-0001-8357-1252
Ahmed N AlbatinehDepartment of Biostatistics and Health Data Science, College of Health, Lehigh University, Bethlehem, PA 18015, USA.
Bader AlawadhDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Loulwa AlsalemDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Irina Al-KhairiDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.ORCID 0000-0002-3547-9926
Preethi CherianDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Fahad Al-AjmiDepartment of Translational Research, Dasman Diabetes Institute, Dasman 15462, Kuwait.ORCID 0009-0005-1541-3793
Mohammad QaddoumiPharmacology and Therapeutics Department, Faculty of Pharmacy, Kuwait University, Kuwait City 13110, Kuwait.ORCID 0009-0008-9582-3419
Muhammad Abdul-GhaniDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Fahd Al-MullaDepartment of Translational Research, Dasman Diabetes Institute, Dasman 15462, Kuwait.ORCID 0000-0001-5409-3829
Jehad AbubakerDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.ORCID 0000-0003-0681-7305

Funding

Kuwait Foundation for the Advancement of Sciences (KFAS) RA-2011-003 and RA-2019-30
6 · The paper itself

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes mellitus (T2DM) share overlapping pathophysiological mechanisms, including insulin resistance and chronic inflammation. Recent evidence suggests that Orosomucoid-2 (ORM2), an acute-phase immunomodulatory protein, may play a role in metabolic regulation; however, its specific involvement in MAFLD remains unclear. This study examined the association between circulating ORM2 levels and the severity of hepatic steatosis, insulin resistance, and T2DM in a cohort of 449 adults. MAFLD was assessed using FibroScan

Indexed as

Diabetes Mellitus, Type 2Fatty LiverOrosomucoidAdultAgedBiomarkersFemaleHumansInsulin ResistanceMaleMiddle AgedROC CurveBiomarkersOrosomucoiddiabetesethnicityinsulin resistanceobesityORM2

Identifiers

PMID40943248
PMCPMC12428177

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.