Evidence map›Paper›PMID 40943369›Full record

ArticleInternational journal of molecular sciences2025

Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients.

Naam Bahjat Ahmed Adeeb, Hadeer Akram Al-Ani, Nur Aizati Athirah Daud, Ruzilawati Abu Bakar, Imran Ahmad, Dzul Azri Mohamed Noor, Zilfalil Bin Alwi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naam Bahjat Ahmed AdeebHuman Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.
Hadeer Akram Al-AniSchool of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-2683-6207
Nur Aizati Athirah DaudHuman Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0003-4336-9468
Ruzilawati Abu BakarHuman Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0001-5392-4707
Imran AhmadHuman Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0003-0826-4724
Dzul Azri Mohamed NoorSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0002-0161-8203
Zilfalil Bin AlwiHuman Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) is a significant disorder commonly found in patients with cardiovascular diseases and diabetes mellitus. Recent updates have indicated that statins may also contribute to an increased risk of ED. This cross-sectional genetic study involved 246 cardiac patients attending normal visits at Hospital Universiti Sains Malaysia (USM) Kubang Kerian outpatient clinics. The patients were categorized into four groups: statins with ED (group 1), statins without ED (group 2), diabetes with statin without ED (group 3), and healthy patients without diabetes mellitus and statin use (group 4). Six genes were hypothesized to influence ED:

Indexed as

Erectile DysfunctionHydroxymethylglutaryl-CoA Reductase InhibitorsAdultAgedAromataseCross-Sectional StudiesGenetic Predisposition to DiseaseHumansMalaysiaMaleMiddle AgedNitric Oxide Synthase Type IIIPolymorphism, Single NucleotideSteroid 17-alpha-HydroxylaseAromataseCYP17A1 protein, humanCYP19A1 protein, humanHydroxymethylglutaryl-CoA Reductase InhibitorsNitric Oxide Synthase Type IIINOS3 protein, humanSteroid 17-alpha-HydroxylaseatorvastatinCYP17A1CYP19A1erectile dysfunctionNOS3NR2F2-AS1

Identifiers

PMID40943369
PMCPMC12428966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.