Evidence map›Paper›PMID 40943391›Full record

ArticleInternational journal of molecular sciences2025

Modulation of

Jeffrey Chi-Fei Wang, Hung-Tsung Hsiao, Sheng-Nan Wu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeffrey Chi-Fei WangDepartment of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-2795-0906
Hung-Tsung HsiaoDepartment of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-0836-707X
Sheng-Nan WuDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-5208-3253

Funding

An Nan Hospital, Tainan, Taiwan ANHRF-114-43 and 114-049 (awarded to S.N.W.)National Chengkung hospital of national Chengkung University NCKUH-11402064 (awarded to H.H.)the National Science and Technology Council, Taiwan NSTC 114-2314-B-006-059- (awarded to H.H.), MOST-109-2314-B-006-033-MY3 (awarded to C.F.W) and NSTC-112-2923-B-006-001 (awarded to S.N.W.)
6 · The paper itself

Abstract

QX-314 is a positively charged lidocaine derivative with the membrane-impermeant property. This compound applied at the intracellular side has been shown to suppress the voltage-gated Na

Indexed as

LidocainePituitary NeoplasmsSodiumAnimalsCell Line, TumorHumansRatsLidocaineSodiumcurrent kineticserg-mediated K+ currenthyperpolarization-activated cation currentQX-314 (N-(2,6-dimethylphenylcarbamoylmethyl) triethylammonium bromide)Voltage-dependent hysteresisvoltage-gated Na+ current

Identifiers

PMID40943391
PMCPMC12428503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.