Evidence map›Paper›PMID 40943496›Full record

ArticleInternational journal of molecular sciences2025

ZFHX3 Knockdown Enhances Metabolic Distress in Atrial Myocytes Through Mitochondrial and Calcium Dysregulation: Mitigation by Trimetazidine.

Baigalmaa Lkhagva, Shuen-Hsin Liu, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Baigalmaa LkhagvaGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0009-0004-5206-9234
Shuen-Hsin LiuGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Satoshi HigaCardiac Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine, Makiminato Central Hospital, 1199 Makiminato, Urasoe 901-2131, Japan.ORCID 0000-0002-5735-6249
Yu-Hsun KaoGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yi-Jen ChenGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-7224-4491

Funding

Foundation for the Development of Internal Medicine in Okinawa, Japan 4-02-003; 4-02-006; 5-02-007National Science and Technology Council 112-2811-B-038-049; 113-2314-B-038-063-MY3Taipei Medical University - Shuang Ho Hospital 114TMU-SHH-21
6 · The paper itself

Abstract

Metabolic dysregulation in the heart plays a critical role in the pathogenesis of atrial fibrillation (AF), yet the underlying molecular mechanisms remain unclear. Loss-of-function variants in the zinc finger homeobox 3 gene (

Indexed as

CalciumHeart AtriaHomeodomain ProteinsMitochondriaMitochondria, HeartMyocytes, CardiacTrimetazidineAnimalsAtrial FibrillationCell LineEnergy MetabolismGene Knockdown TechniquesGlucoseMiceCalciumGlucoseHomeodomain ProteinsTrimetazidineatrial fibrillationlactatemitochondrial Ca2+mitochondrial energy metabolismtrimetazidinezinc finger homeobox 3 (ZFHX3)

Identifiers

PMID40943496
PMCPMC12429405

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.