Evidence map›Paper›PMID 40943499›Full record

ArticleInternational journal of molecular sciences2025

Neurotransmitter Genes in the Nucleus Accumbens That Are Involved in the Development of a Behavioral Pathology After Positive Fighting Experiences and Their Deprivation: A Conceptual Paradigm for Data Analysis.

Natalia N Kudryavtseva, Dmitry A Smagin, Olga E Redina, Irina L Kovalenko, Anna G Galyamina, Vladimir N Babenko

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia N KudryavtsevaPavlov Institute of Physiology RAS, Saint Petersburg 199034, Russia.ORCID 0000-0003-2418-1750
Dmitry A SmaginFRC Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0002-4017-7287
Olga E RedinaFRC Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0003-0942-8460
Irina L KovalenkoFRC Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0002-6672-1287
Anna G GalyaminaFRC Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0001-6101-2521
Vladimir N BabenkoFRC Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0002-3077-9559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown previously that repeated positive fighting experience in daily agonistic interactions is accompanied by the development of psychosis-like behavior, with signs of an addiction-like state associated with changes in the expression of genes encoding the proteins involved in the main neurotransmitter events in some brain regions of aggressive male mice. Fighting deprivation (a no-fight period of 2 weeks) causes a significant increase in their aggressiveness. This paper is aimed at studying-after a period of fighting deprivation-the involvement of genes (associated with neurotransmitter systems within the nucleus accumbens) in the above phenomena. The nucleus accumbens is known to participate in reward-related mechanisms of aggression. We found the following differentially expressed genes (DEGs), whose expression significantly differed from that in controls and/or mice with positive fighting experience in daily agonistic interactions followed by fighting deprivation: catecholaminergic genes

Indexed as

AggressionBehavior, AnimalNeurotransmitter AgentsNucleus AccumbensAnimalsGene Expression ProfilingGene Expression RegulationMaleMiceNeurotransmitter Agentsfighting deprivationneurotransmitter differentially expressed genenucleus accumbenspositive fighting experience

Identifiers

PMID40943499
PMCPMC12429646

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.