Evidence map›Paper›PMID 40943556›Full record

ArticleInternational journal of molecular sciences2025

Sea Urchin Pigment Ethylspinazarin (U-573): A Novel P2X7 Receptor Antagonist with Neuroprotective and Antiparkinsonian Effects.

Evgeny Pislyagin, Sergey Kozlovskiy, Irina Agafonova, Ekaterina Menchinskaya, Ekaterina Chingizova, Tatiana Gorpenchenko, Anatolii Mirochnik, Elena Fedorenko, Yuri Sabutski, Sergei Polonik and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Evgeny PislyaginG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0002-3558-0821
Sergey KozlovskiyG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0001-9961-8350
Irina AgafonovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0002-5587-2610
Ekaterina MenchinskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.
Ekaterina ChingizovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0003-0093-5757
Tatiana GorpenchenkoFederal Scientific Center of East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-9419-7523
Anatolii MirochnikInstitute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia.
Elena FedorenkoInstitute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia.
Yuri SabutskiG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0003-3815-6142
Sergei PolonikG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.
Dmitry AmininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0002-1073-4994

Funding

Russian Academy of Sciences 075-03-2025-231Russian Science Foundation 24-74-10081
6 · The paper itself

Abstract

The ability of the quinonoid sea urchin pigment ethylspinazarin (U-573) to protect mouse Neuro-2a neuronal cells from the neurotoxic effect of one of the Parkinson's disease inducers, MPP+, was studied. This compound blocked Ca

Indexed as

Antiparkinson AgentsNaphthoquinonesNeuroprotective AgentsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Sea UrchinsAdenosine TriphosphateAnimalsCell SurvivalDisease Models, AnimalMaleMiceNeuronsAdenosine TriphosphateAntiparkinson AgentsNaphthoquinonesNeuroprotective AgentsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X71,4-naphthoquinonesneuronal cellsneuroprotectionP2X7RParkinson’s disease

Identifiers

PMID40943556
PMCPMC12429682

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.