Evidence map›Paper›PMID 40943577›Full record

ArticleInternational journal of molecular sciences2025

Decoding Thalamic Glial Interplay in Multiple Sclerosis Through Proton Magnetic Resonance Spectroscopy and Positron Emission Tomography.

Firat Kara, Nur Neyal, Michael G Kamykowski, Christopher G Schwarz, June Kendall-Thomas, Holly A Morrison, Matthew L Senjem, Scott A Przybelski, Angela J Fought, John D Port and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Neurobiology of aging · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Firat KaraDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-4679-8110
Nur NeyalDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Michael G KamykowskiDepartment of Information Technology, Mayo Clinic, Rochester, MN 55905, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
June Kendall-ThomasDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Holly A MorrisonMayo Clinic Center for MS and Autoimmune Neurology, Rochester, MN 55905, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Scott A PrzybelskiDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Angela J FoughtDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
John D PortDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4237-7776
Dinesh K DeelchandCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4266-4780
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-5612-1667
Gülin ÖzCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5769-183X
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Orhun H KantarciDepartment of Neurology, Mayo Clinic-Minnesota, Rochester, MN 55905, USA.
Burcu ZeydanDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2270-9868

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
NIAMS NIH HHS K12 AR084222NIBIB NIH HHS P41 EB027061NICHD NIH HHS K12 HD065987NIH HHS K12 AR084222NIH HHS K12 HD065987NINDS NIH HHS R01 NS080816NINDS NIH HHS R01NS080816
6 · The paper itself

Abstract

The study assesses the relationship between thalamic proton-MR spectroscopy (

Indexed as

Multiple SclerosisNeurogliaPositron-Emission TomographyProton Magnetic Resonance SpectroscopyThalamusAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective Studies11C-ER176 TSPO positron emission tomographygliosismultiple sclerosisproton magnetic resonance spectroscopythalamus

Identifiers

PMID40943577
PMCPMC12428814

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.