Effect of Estrogen on Sirt1 Signaling in Human Macrophages.

Maria Luisa Barcena, Anne Breiter, Julia Temp, Yury Ladilov, Vera Regitz-Zagrosek

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Luisa BarcenaDepartment of Urology, Eberhard Karls University of Tuebingen, 72074 Tuebingen, Germany.ORCID 0000-0003-1391-9262

Anne BreiterBerlin Institute of Health, Institute for Gender in Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.

Julia TempDepartment of Urology, Eberhard Karls University of Tuebingen, 72074 Tuebingen, Germany.

Yury LadilovBrandenburg Medical School Theodor Fontane, Department of Cardiovascular Surgery, Heart Center Brandenburg, University Hospital, 16321 Bernau bei Berlin, Germany.ORCID 0000-0002-9836-8801

Vera Regitz-ZagrosekBerlin Institute of Health, Institute for Gender in Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases are the leading cause of human death worldwide. The role of the female hormone estrogen (E2) in this context is subject of debate. E2 might counteract inflammation by acting on macrophages; however, the underlying cellular mechanisms remain poorly understood. In the current study, we used primary human macrophages to investigate the effects of E2 on the NAD

Indexed as

EstrogensMacrophagesSignal TransductionSirtuin 1AcetylationAdultCells, CulturedFemaleHumansKu AutoantigenLipopolysaccharidesMaleTranscription Factor RelATumor Suppressor Protein p53EstrogensKu AutoantigenLipopolysaccharidesSIRT1 protein, humanSirtuin 1Transcription Factor RelATumor Suppressor Protein p53acetylationmacrophage-like cellsnucleus isolationsex differencesSirt1

Identifiers

PMID40943592

DOI10.3390/ijms26178670

PMCPMC12428810

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.