Evidence mapPaperPMID 40943606Full record

ReviewInternational journal of molecular sciences2025

Innovative Approaches to Medical Rehabilitation: Regeneration, Immune Training, Homeostasis, and Microbiome Synergy.

Enrico Garaci, Matteo Antonio Russo, Marilena Pariano, Matteo Puccetti, Consuelo Fabi, Sarah Balucchi, Marina Maria Bellet, Maurizio Ricci, Massimo Fini, Luigina Romani

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Enrico GaraciSan Raffaele Research Center, 67039 Sulmona, Italy.
Matteo Antonio RussoIRCCS San Raffaele, 00163 Rome, Italy.ORCID 0000-0002-5847-6015
Marilena ParianoDepartment of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-9896-171X
Matteo PuccettiDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Consuelo FabiDepartment of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0009-0008-2396-073X
Sarah BalucchiDepartment of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Marina Maria BelletDepartment of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0001-7604-0189
Maurizio RicciDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-3373-9771
Massimo FiniIRCCS San Raffaele, 00163 Rome, Italy.
Luigina RomaniSan Raffaele Research Center, 67039 Sulmona, Italy.ORCID 0000-0002-1356-525X

Funding

HDM-FUN 847507
6 · The paper itself

Abstract

This article explores an integrative framework for medical rehabilitation that combines regenerative medicine, systemic homeostasis, and microbiome modulation to optimize recovery and long-term health. Moving beyond conventional rehabilitation approaches focused on symptomatic recovery, this multidimensional paradigm emphasizes cellular repair, physiological balance, and microbial health as interdependent pillars of effective recovery. The framework leverages advancements in stem cell therapy, immune system modulation, and microbiota-targeted interventions to address both immediate functional restoration and long-term systemic resilience. By highlighting the synergistic interplay between these components, this article provides actionable insights into transforming medical rehabilitation into a proactive and holistic endeavor, paving the way for enhanced therapeutic outcomes and sustained patient well-being.

Indexed as

HomeostasisMicrobiotaRegenerationRegenerative MedicineRehabilitationAnimalsHumansholistic rehabilitationimmunological trainingmicrobiome modulationregenerative medicinesystemic homeostasis

Identifiers

PMID40943606
PMCPMC12429726

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.