Evidence map›Paper›PMID 40944126›Full record

Trial reportNutrients2025

Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.

Brooke A Napier, Jessica R Allegretti, Paul Feuerstadt, Colleen R Kelly, Nicholas W Van Hise, Ralf Jäger, Zain Kassam, Gregor Reid

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brooke A NapierSeed Health, Inc., Venice, CA 90291, USA.ORCID 0000-0002-6409-4750
Jessica R AllegrettiDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Paul FeuerstadtDepartment of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06510, USA.
Colleen R KellyDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Nicholas W Van HiseMetro Infectious Disease Consultants, Burr Ridge, IL 60527, USA.
Ralf JägerIncrenovo LLC, Whitefish Bay, WI 53217, USA.ORCID 0000-0002-7345-9635
Zain KassamSeed Health, Inc., Venice, CA 90291, USA.
Gregor ReidCanadian R&D Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, ON N6A 4V2, Canada.ORCID 0000-0001-9658-5696

Funding

Seed Health, Inc. N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ButyratesCoumarinsGastrointestinal MicrobiomeInflammationSynbioticsAdultBifidobacteriumDietary SupplementsDouble-Blind MethodFecesFemaleHealthy VolunteersHumansMaleMiddle AgedPlant Extracts3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneButyratesCoumarinsPlant Extractsmicrobiomeprebioticprobioticshort-chain fatty acidssynbioticurolithin

Identifiers

PMID40944126
PMCPMC12430871

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.