Evidence map›Paper›PMID 40944265›Full record

ReviewNutrients2025

The Neuroprotective Potential of

Alexandru Vasincu, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei, Delia Bulea, Oana Dana Arcan, Ioana Mirela Vasincu, Sorin Beșchea Chiriac, Ionuț-Răducu Popescu, Walther Bild, Veronica Bild

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Ethnobotany, Phytochemistry, and Pharmacological Activities ofInternational journal of molecular sciences · 2026
    Pooled it
  2. Article
  3. Plants (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandru VasincuDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0002-3948-6496
Răzvan-Nicolae RusuDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0003-4799-325X
Daniela-Carmen AbabeiDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0001-5568-2123
Delia BuleaDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Oana Dana ArcanDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Ioana Mirela VasincuDepartment of Pharmaceutical Chemistry, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0002-0873-2789
Sorin Beșchea ChiriacDepartment of Veterinary Toxicology, "Ion Ionescu de la Brad" University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iasi, Romania.
Ionuț-Răducu PopescuDepartment of Physiology, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0009-0001-4260-9565
Walther BildDepartment of Physiology, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0003-4923-8020
Veronica BildDepartment of Pharmacodynamics and Clinical Pharmacy, "Grigore T Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0003-1636-0345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases (NDs) encompass a group of chronic conditions, characterized by neuronal losses in large areas of the brain, leading to cognitive and behavioral impairments. Alzheimer's Disease (AD), the most common form of dementia, is a progressive ND, characterized by the accumulation of amyloid β and tau protein, entails cognitive decline, neuroinflammation, mitochondrial dysfunction, and blood-brain barrier impairment, with oxidative stress playing a critical role in its pathogenesis. To date, the available pharmacotherapy has shown limited efficacy, and multitarget activity of plant-derived neuroprotective bioactive compounds is currently in focus. This review synthesizes experimental evidence regarding

Indexed as

Alzheimer DiseaseNeuroprotective AgentsOcimumOcimum basilicumOcimum sanctumPlant ExtractsAnimalsAntioxidantsBrainHumansNeurodegenerative DiseasesOxidative StressAntioxidantsNeuroprotective AgentsPlant ExtractsAlzheimer’s diseaselipid peroxidationneurodegenerative diseaseOcimum sp.oxidative stress

Identifiers

PMID40944265
PMCPMC12430141

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.