Evidence map›Paper›PMID 40944291›Full record

ArticleNutrients2025

A Hypoglycemic Peptide from

Zhe-Xuan Mu, Zhen-Zhou Li, Bing-Xiao Liu, Zhen-Yu Wang, Xiao-Hong Lv, Lin Yang, Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe-Xuan MuDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.ORCID 0009-0000-1496-0393
Zhen-Zhou LiDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Bing-Xiao LiuDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Zhen-Yu WangDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Xiao-Hong LvForestry and Grassland Germplasm Resources Research Center, Heilongjiang Academy of Forestry, Harbin 150081, China.
Lin YangDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Hua ZhangDepartment of Special Food and Drug and Biochemical Innovation Research Center, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0002-1262-2195

Funding

National Key Research and Development Program of China 2022YFF1300504
6 · The paper itself

Abstract

BACKGROUND AND

methodsTo address the need for dietary interventions in sub-healthy populations and promote sustainable utilization of agricultural by-products, we isolated

resultsPHP exhibited significant inhibitory activity against α-amylase and α-glucosidase. In type 2 diabetic mice, PHP significantly ameliorated the "three-more-one-less" syndrome, reduced glycosylated hemoglobin and insulin levels, mitigated liver and kidney tissue lesions, and improved glucose and lipid metabolic disorders-effects partly supported by its enhancement of intestinal barrier function via restoring gut microbiota diversity. Gut microbiota analysis revealed that PHP exerts hypoglycemic effects by regulating gut microbial composition: increasing SCFA-producing taxa, reducing pro-inflammatory/metabolic disorder-associated taxa, and normalizing the Firmicutes/Bacteroidetes ratio. KEGG pathway analysis demonstrated that PHP mediates synergistic hypoglycemic effects by regulating carbohydrate metabolism, amino acid metabolism, and cofactor/vitamin metabolism.

conclusionsThis work provides a theoretical foundation for developing natural functional foods from agricultural by-products, supporting PHP's potential as a dietary supplement for metabolic regulation.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2GlycolipidsHypoglycemic AgentsNutsPeptidesPinusPlant Oilsalpha-AmylasesAnimalsBlood GlucoseGastrointestinal MicrobiomeInsulinLipid MetabolismMaleMicealpha-AmylasesBlood GlucoseGlycolipidsHypoglycemic AgentsInsulinPeptidesPlant Oilsagricultural by-product utilizationglycolipid metabolism regulationgut microbiota modulationKEGG pathway analysisPinus pumila bioactive peptides

Identifiers

PMID40944291
PMCPMC12430382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.