Evidence map›Paper›PMID 40944409›Full record

ArticleActa biochimica et biophysica Sinica2025

Angptl4 is upregulated by microenvironmental factors during the wound healing process and promotes epidermal stem cell proliferation via PRL8a6.

Siyuan Yu, Pengxiang Ji, Ting Du, Zuohua Liu, Yuan Yang, Zhenkun Lv, Lei Xu, Qianheng Jin, Weijuan Gong, Yingying Le and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siyuan YuTeaching Hospital of Yangzhou University Medical College, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Pengxiang JiDepartment of Hand Surgery, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Ting DuTeaching Hospital of Yangzhou University Medical College, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Zuohua LiuSuzhou Ruihua Orthopedic Hospital, Suzhou Medical College of Soochow University, Suzhou 215104, China.
Yuan YangDepartment of Hand Surgery, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Zhenkun LvSuzhou Ruihua Orthopedic Hospital, Suzhou Medical College of Soochow University, Suzhou 215104, China.
Lei XuDepartment of Hand Surgery, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Qianheng JinDepartment of Hand Surgery, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.
Weijuan GongDepartment of Immunology, Yangzhou University Medical College, Yangzhou 225009, China.
Yingying LeShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yi FuDepartment of Human Anatomy, Histology and Embryology, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Ruixing HouTeaching Hospital of Yangzhou University Medical College, Suzhou Ruihua Orthopedic Hospital, Suzhou 215104, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiopoietin-like 4 (ANGPTL4) expression is increased in wound tissue and contributes to wound healing. However, the underlying mechanisms are not fully understood. Here, we demonstrate that ANGPTL4 expression is significantly increased in epidermal stem cells (EpSCs) in the periwound epidermis during wound healing in mice. Increased Angptl4 expression is positively correlated with increased expressions of tumor growth factor-α, interleukin-1β, epidermal growth factor, nerve growth factor, fibroblast growth factor 7, and transforming growth factor-β1. Each of these molecules induces Angptl4 expression in mouse EpSCs. RNA sequencing of EpSCs derived from wild-type and Angptl4 knockout (Angptl4

Indexed as

angiopoietin-like 4cell proliferationepidermal stem cellsprl8a6wound healing

Identifiers

PMID40944409
PMCPMC12748188

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.