ArticleJACC. Asia2025
Sleep Patterns and Frailty: Joint Impact on Major Adverse Cardiac Events.
Article in JACC. Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The effect of caffeinated beverage consumption on the relationship between sleep quality and major adverse cardiovascular events: Sleep Heart Health Study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep patterns and frailty phenotypes are becoming increasingly important metrics for assessing cardiovascular disease (CVD) risk; however, research investigating their synergistic effects on major adverse cardiac events (MACE) remains scarce.
objectivesThis study aimed to investigate how sleep patterns and frailty phenotypes jointly influence MACE.
methodsA total of 380,105 participants from the UK Biobank were included for the analysis. Frailty phenotypes and sleep patterns were defined based on the frailty scores and sleep scores, respectively. Cox proportional hazards models were used to evaluate the associations between combinations of frailty phenotypes and sleep patterns and MACE, including nonfatal myocardial infarction, stroke, or CVD-related death.
resultsAfter a median follow-up period of 12.94 years (Q1-Q3: 12.23-13.64 years), 18,074 participants experienced incident MACE, with an incidence rate of 3.73 per 1,000 person-years (95% CI: 3.68-3.79). Compared with participants with frailty and poor sleep patterns, nonfrail participants with healthy sleep patterns have the lowest risk of MACE (HR: 0.560; 95% CI: 0.445-0.704; P < 0.001) and other secondary outcomes. Maintaining a healthy sleep pattern was associated with a reduced risk of MACE among the pre-frail participants (HR: 0.815; 95% CI: 0.732-0.853; P < 0.001). These findings remained robust across a series of sensitivity analyses and various subgroups.
conclusionsMaintaining a healthy sleep pattern and a nonfrail status were jointly associated with a significantly decreased risk of MACE. These results emphasize the importance of promoting sleep health to mitigate CVD risk in prefrail participants.
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