Evidence map›Paper›PMID 40944770›Full record

ArticleBrain tumor pathology2026

Meningioma with trabecular architecture: a harbinger of BAP1 deficiency.

Noriko Okuno, Takahiro Tomita, Takuya Akai, Satoshi Kuroda, Hiromasa Takakura, Kenichi Hirabayashi, Masakiyo Sasahara, Akira Kurose, Katsuyoshi Takata

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In one paragraph

Article in Brain tumor pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Noriko OkunoDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan. nsshr25@med.u-toyama.ac.jp.
Takahiro TomitaDepartment of Neurosurgery, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, Japan.
Takuya AkaiDepartment of Neurosurgery, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, Japan.
Satoshi KurodaDepartment of Neurosurgery, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, Japan.
Hiromasa TakakuraDepartment of Otolaryngology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, Japan.
Kenichi HirabayashiDepartment of Diagnostic Pathology, Toyama University Hospital, Toyama, Toyama, Japan.
Masakiyo SasaharaDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Akira KuroseDepartment of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Katsuyoshi TakataDepartment of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRCA (BReast CAncer gene)-associated protein 1 (BAP1) is a tumor suppressor protein encoded by the BAP1 gene. BAP1 mutations and the loss of BAP1 expression on immunohistochemistry are poor prognostic factors for meningiomas. These mutations have been previously reported in papillary and rhabdoid meningiomas. However, BAP1-deficient meningiomas with a trabecular architecture are rare, with only one previous report describing two cases. Here, we present the case of an 80-year-old male who experienced two recurrences of meningiomas over a 14-year period. The initial tumor exhibited a mixture of typical meningothelial meningioma and meningioma with trabecular architecture, whereas the second recurrence was almost entirely trabecular. Immunohistochemical analysis revealed a BAP1 deficiency. This case highlights the importance of the trabecular architecture as a histological pattern that may indicate BAP1 loss and poor prognosis. Given the potential for targeted therapies, further research is needed to establish this histological subtype as an independent entity with poor prognosis.

Indexed as

Meningeal NeoplasmsMeningiomaTumor Suppressor ProteinsUbiquitin ThiolesteraseAged, 80 and overHumansImmunohistochemistryMaleMutationNeoplasm Recurrence, LocalPrognosisBAP1 protein, humanTumor Suppressor ProteinsUbiquitin ThiolesteraseBAP1Brain TumorCentral Nervous SystemMeningiomaTrabecular Architecture

Identifiers

PMID40944770

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.