ArticleInternational urology and nephrology2026
Experimental study on the prevention of iodinated contrast-induced kidney injury in rats by tetramethylpyrazine and the detection of their renal function by intravoxel incoherent motion.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeExperimental study on tetramethylpyrazine (TMP) for preventing contrast-induced renal injury in rats using magnetic resonance intravoxel incoherent motion (IVIM) to assess renal water diffusion properties and perfusion.
methodsEighty-four Sprague-Dawley(SD) male rats were divided into four groups: control (saline), CI-AKI (iohexol 2.5 g I/kg), CI-AKI + TMP (iohexol2.5 g I/kg + 80 mg/kg TMP), and CI-AKI + saline. The IVIM images were acquired longitudinally at baseline and 1, 24, 48, and 72 h after the administration of the drugs to evaluate the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion-related value (D*), and perfusion fraction (f) values. Serum creatinine (SCR), histology, and hypoxia-inducible factor-1α (HIF-1α) immunoexpression were determined.
resultsIn the control group, there were no significant changes in ADC, D, D*, and f values of renal cortex (CO), outer medulla (OM), and inner medulla (IM) at all time points. In the CI-AKI group, ADC, D, D*, and f values of renal CO, OM, and IM reached the lowest level at 48 h (p < 0.05). In the CI-AKI + TMP group, the ADC, D, D*, and f values of renal CO, OM, and IM were significantly higher than those of the CI-AKI group at 48 h and 72 h. In particular, these values returned to baseline levels by 72 h. No improvement was observed in the CI-AKI + saline group. ADC, D, D *, and f values negatively correlated with renal injury score (all p < 0.001, r = -0.845 to 0.913) and HIF-1α expression (all p < 0.001, r = -0.846 to 0.920).
conclusionTMP prevents early contrast-induced renal injury and allows noninvasive detection of renal water diffusion properties and perfusion function by IVIM.
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