ArticleVeterinary medicine and science2025
Serum Amyloid A and Haptoglobin as Markers in Cats with Gingivitis-Preliminary Study.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Clinical periodontal indices are associated with systemic inflammatory and oxidative stress biomarkers in dogs with periodontal disease.Veterinary and animal science · 2026Article
- Combination Therapeutic Effect of Antibacterial and Antiviral Agents on Feline Chronic Gingivostomatitis Nonbounded to Prior Tooth Extraction Confirmed by Physical Signs and Clinical Biomarkers.Veterinary sciences · 2026Article
- Serum Amyloid A and Haptoglobin as Markers in Cats with Gingivitis-Preliminary Study.Veterinary medicine and science · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic gingivostomatitis has been associated with increases in α1-acid glycoprotein and serum haptoglobin (Hp) in cats. However, serum amyloid A (SAA) and Hp have not been previously evaluated in cats with uncomplicated gingivitis.
objectivesTo compare SAA and Hp between cats with gingivitis and healthy cats, and to investigate the correlation between these two proteins and the severity of gingivitis.
methodsThis was a prospective cross-sectional study. Adult, FIV- and FeLV-seronegative cats were included. The cats were allocated into two age- and sex-matched groups. The case group included cats with gingivitis, and the control group included clinically and clinicopathologically healthy cats. The severity of gingivitis was assessed by the Total Mouth Periodontal Score (TMPS)-G index. Serum samples were used to measure SAA and Hp using a previously validated turbidimetric immunoassay and haemoglobin-binding method, respectively. The R statistical language was used for the statistical analysis.
resultsA total of 22 cats were included, 11 in each study group. The median (range) age of cats was 5.0 (3.0-11.0) years. The median Hp concentration was significantly higher (p = 0.001) in the case group (2.40 [0.72-4.44] g/L) compared with the control group (1.06 [0.50-1.42] g/L). A significant correlation was found between Hp and TMPS-G (rho = 0.636, p = 0.040). The SAA was below the detection limit (0.4 mg/L) in all samples of the control group and in 10/11 samples of the case group.
conclusionsFeline gingivitis is associated with increased Hp, suggesting the presence of an acute-phase reaction. Haptoglobin appears to be correlated with the severity of the disease.
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