ReviewJournal of advanced research2026
Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Circular RNAs in metabolic health: bridging the gap between molecular biology and therapy.Cell death & disease · 2026Review
- Exosomal circRNAs in hepatocellular carcinoma: Implications for the development and therapeutic resistance of hepatocellular carcinoma (Review).International journal of oncology · 2026Review
- Research on the role and mechanisms of Cystatin 6 in disease pathosis and development.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with limited therapeutic options. Circular RNAs (circRNAs) have emerged as key regulators in HCC. They influence oncogenic pathways by acting as microRNA (miRNA) sponges, protein interaction mediators, and exosomal messengers, and their protein-coding potential further boosts their functional importance in cancer progression. AIM OF REVIEW: This review aims to evaluate the roles of circRNA-encoded proteins in HCC metastasis, apoptosis, therapy resistance, and metabolic reprogramming. It also discusses the latest detection methods and RNA-based therapeutic strategies. KEY SCIENTIFIC CONCEPTS OF REVIEW: circRNAs-encoded proteins can modulate key cellular processes and serve as promising biomarkers and therapeutic targets. The review integrates findings across cancer types and emphasizes current challenges in delivery, detection sensitivity, and mechanistic elucidation. Tackling these issues will be essential for translating circRNA-derived proteins into precision medicine for HCC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.