Evidence map›Paper›PMID 40946106›Full record

ReviewEuropean biophysics journal : EBJ2025

Voltage-sensing domains: structural and functional diversity.

Martin C Heiss, Bernhard E Flucher

Abstract readReview
PubMed Publisher
In one paragraph

Review in European biophysics journal : EBJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Martin C HeissDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-5535-2941
Bernhard E FlucherDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, 6020, Innsbruck, Austria. bernhard.e.flucher@i-med.ac.at.ORCID http://orcid.org/0000-0002-5255-4705

Funding

Austrian Science Fund P35618
6 · The paper itself

Abstract

Voltage-sensing domains (VSDs) are structural modules of voltage-gated ion channels, which sense changes in the membrane potential and, in response, open and close the channel's ion conduction pore. VSDs comprise a bundle of four antiparallel transmembrane helices (S1-S4). Their basic function is well described by the sliding helix model. Upon membrane depolarization, the positively charged S4 helix slides upward and several of its positive gating charges cross the focused membrane electric field. This state transition is conformationally coupled to the opening of the channel gate. While this essential mechanism is common to all VSDs, different VSDs display a considerable structural and functional diversity, including the number of the gating charges, the nature of their countercharges, and the range, speed, and voltage dependence of the S4 movement upon activation. Here, we review these differences and discuss how they might function to determine the distinct gating properties of voltage-gated ion channels.

Indexed as

charge transfer centercounterchargesgating chargeshydrophobic constriction siteVoltage-gated ion channelsVoltage-sensing domains

Identifiers

PMID40946106

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.