ArticleInternational urology and nephrology2026
Effect of resveratrol on the renal cell morphology in acute restraint stress-induced male adult Wistar albino rat model, a pilot study.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe goal was to observe the microscopic picture of the kidney in acute restraint stress-induced male adult Wistar albino rat model and to study the beneficial effect of resveratrol (RSV) on it.
methodsThe rats were divided into three groups of six animals each, including control, experimental, and treatment groups. Stress was induced by keeping the rats immobilized in a rigid opaque plastic cylinder for 2 weeks, which restrained their movements. The treatment group received RSV orally 10 mg/kg body weight for two more weeks after the initial 2-week period of stress induction. The EGTI scoring system was considered to assess the renal injury.
resultsThe kidneys of the stress-induced group exhibited congested and swollen glomeruli, increased cellularity, basement membrane thickness, and glomerular tuft retraction. There were interstitial edema, glomeruli puckering, and the Bowman's space extension. Renal tubules showed hyaline casts, granular degeneration, loss of brush border, and necrosis. Blood vessels were thickened, and the lumens were occluded. A few locations also revealed congested and dilated blood vessels. Interstitium showed focal aggregates of acute and chronic inflammation. Due to the stress, the EGTI renal injury score was seven (7/14). The treatment group revealed reversal of pathological changes observed at the glomerulus and convoluted tubules.
conclusionAccording to this study, RSV appears to be nephroprotective as it reversed most of the pathological changes induced by the acute restraint stress. However, the treatment with RSV followed the withdrawal of stress which is a potential limitation of this study design. A better conclusion can be drawn if RSV and stress are parallelly administered.
Indexed as
Identifiers
40946259What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.