Evidence map›Paper›PMID 40947104›Full record

ArticlePediatric obesity2025

Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood.

Janice M Y Hu, Michael M Borghese, Mandy Fisher, Joseph M Braun, Katherine M Morrison, Mark R Palmert, Linda Booij, Constadina Panagiotopoulos, Jillian Ashley-Martin

Abstract read
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In one paragraph

Article in Pediatric obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Janice M Y HuEnvironmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.ORCID https://orcid.org/0009-0006-4416-9184
Michael M BorgheseEnvironmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.
Mandy FisherEnvironmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-5239-3235
Katherine M MorrisonDepartment of Pediatrics, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-1737-256X
Mark R PalmertDivision of Endocrinology, Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Linda BooijDepartment of Psychiatry and Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Constadina PanagiotopoulosDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Jillian Ashley-MartinEnvironmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.

Funding

Canadian Institutes for Health Research MOP-81285Government of CanadaOntario Ministry of the Environment
6 · The paper itself

Abstract

introductionChildhood obesity is a public health concern. Studies have investigated the effects of metal mixtures on childhood obesity but none have identified periods of heightened susceptibility of exposure. We identified the periods by investigating the association of metal mixture, measured at four time points, with adiposity. MATERIALS AND

methodsUsing data from the Maternal-Infant Research on Environmental Chemicals Research Platform, we included 234 child-parent pairs. We measured whole blood metal concentrations during the first and third trimesters, early and late childhood. Outcomes were late childhood body mass index z-score (zBMI), body fat percentage (%BF) and waist circumference z-score (zWC). We used treed distributed lag mixture models (TDLMM) to investigate associations between metal mixture and adiposity. We also investigated associations using linear regression and conducted sex-specific analysis.

resultsAmong females, arsenic was positively associated with zBMI and zWC. Regression results show that each doubling in third trimester arsenic concentrations was associated with 0.16 (95% CI: 0.02, 0.31) and 0.13 (95% CI: 0.01, 0.25) increase in zBMI and zWC, respectively. TDLMM results were similar but attenuated. We also observed negative associations between third trimester cadmium and zWC, null associations between other metals and adiposity and among males and no metal interactions.

conclusionThird trimester is a period of heightened susceptibility to obesogenic effects of arsenic exposure in females.

Indexed as

AdiposityArsenicEnvironmental ExposureMaternal ExposureMetalsPediatric ObesityPrenatal Exposure Delayed EffectsAdultBody Mass IndexChildChild, PreschoolFemaleHumansMalePregnancyPregnancy Trimester, ThirdArsenicMetalsarsenicbody mass index (BMI)childhood obesitymetal mixtureperiods of heightened susceptibilitytree distributed lag mixture modelwaist circumference

Identifiers

PMID40947104
PMCPMC12590100

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.