In one paragraphReview in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Kevin A MurachMolecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, Arkansas, USA.ORCID 0000-0003-2783-7137 Cory M DunganDepartment of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.
Toby L ChambersMolecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, Arkansas, USA.ORCID 0000-0001-7567-1819 Steve HorvathDepartment of Human Genetics, University of California los Angeles, California, Los Angeles, USA.ORCID 0000-0002-4110-3589 Jayakrishnan NandakumarDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9146-2785 Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0372-7016 Scott D PletcherDepartment of Molecular & Integrative Physiology, Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Xiaoting DaiDepartment of Molecular & Integrative Physiology, Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Longhua GuoDepartment of Molecular & Integrative Physiology, Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9690-9750 Funding
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2MUnderstanding Cross-National Health Differences at Older Ages and Their CausesR01AG063944 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI BOERSCH-SUPAN, AXEL H, CRIMMINS, EILEEN M · 2019 to 2024
$3.2MMediators of Muscle Rejuvenation with AgingR01AG080047 · NIA · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Kevin Murach · 2023 to 2026
$2.3MTurning back biological clock: mechanisms of age reversal in a whole organismDP2AG093207 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUO, LONGHUA · 2024 to 2024
$1.4MMyonuclear Epigenetics of Skeletal Muscle Mass Regulation with AgeR00AG063994 · NIA · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MURACH, KEVIN · 2021 to 2023
$735kImaging spatial transcriptome at single cell resolution to study eye regeneration in old ageR21AG084959 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUO, LONGHUA · 2023 to 2025
$624kMediators of Muscle Rejuvenation with AgingK02AG088465 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kevin Murach · 2025 to 2026
$285kAmerican Federation for Aging ResearchHevolutionNIA NIH HHS DP2 AG093207NIA NIH HHS K02 AG088465NIA NIH HHS P30 AG024824NIA NIH HHS R00 AG063994NIA NIH HHS R01 AG063944NIA NIH HHS R01 AG080047NIA NIH HHS R21 AG084959NIH HHS K02 AG088465NIH HHS R00 AG063944NIH HHS R01 AG080047NIH HHS R01 AG080047-02S1
6 · The paper itselfAbstract
Adult resident stem cells are capable of regenerating tissues that manifest signs of "rejuvenation" in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited in specific tissues and stem cell types of larger mammals. Understanding and harnessing the rejuvenating properties of resident adult stem cells in flatworms and mice could have broad therapeutic implications for improving stem cell function and tissue plasticity across organ systems of humans in advanced age.
Indexed as
Adult Stem CellsAgingPlatyhelminthsRegenerationRejuvenationAnimalsHumansMice
Identifiers
PMID40947308
PMCPMC12611277
What Socratic holds
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LicenceCC BY
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