Evidence map›Paper›PMID 40947352›Full record

ReviewSeminars in perinatology2025

The placenta as a window into neonatal brain injury.

Elmira Bachinsky, Lauren Guyer, Riddhi Patel, Stephen K Amoah, Diana Ortega, Shenandoah Robinson, Hawley Helmbrecht, Lauren L Jantzie

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elmira BachinskyNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: ebachin1@jh.edu.
Lauren GuyerNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: lguyer2@jh.edu.
Riddhi PatelNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Neurosciences Intensive Care Nursery (NICN), Johns Hopkins Children's Center, USA. Electronic address: rpate151@jh.edu.
Stephen K AmoahNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: skamoah@uccsms.edu.gh.
Diana OrtegaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: dortega6@jhu.edu.
Shenandoah RobinsonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Kennedy Krieger Institute, Baltimore, MD, USA; Neurosciences Intensive Care Nursery (NICN), Johns Hopkins Children's Center, USA. Electronic address: srobin81@jhmi.edu.
Hawley HelmbrechtNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Neurosciences Intensive Care Nursery (NICN), Johns Hopkins Children's Center, USA. Electronic address: hhelmbr1@jh.edu.
Lauren L JantzieNeonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Kennedy Krieger Institute, Baltimore, MD, USA; Neurosciences Intensive Care Nursery (NICN), Johns Hopkins Children's Center, USA. Electronic address: ljantzie@jhmi.edu.

Funding

Placental Mediated Mechanisms of Perinatal Brain InjuryR01HL139492 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI JANTZIE, LAUREN LEIGH COONEY · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL139492
6 · The paper itself

Abstract

The placenta serves as an essential communicative organ between a mother and fetus throughout gestation. The placenta is critical in the development and maintenance of pregnancy while serving as a hub for immune signaling. In the context of an ever-changing microenvironment, the placenta responds dynamically to infection, inflammation, and other potentially harmful exposures. As in chorioamnionitis and preterm birth, a placental inflammatory response can impart harm to the developing fetal brain and facilitate the presentation of perinatal brain injury. Through various functional and structural disruptions, including changes to neural networks and complex neural immune interactions, neurodevelopmental disorders can manifest. In this review, we utilize chorioamnionitis as a platform for understanding immune signaling and inflammatory cell communication along the maternal-placental-fetal axis. We delineate how immune dysfunction changes neurodevelopment and explore cellular and molecular mechanisms associated with adverse clinical outcomes after birth. Together with discussion of unique inflammatory pathophysiology and triggers of perinatal brain injury, we explore avenues for neuroimmunomodulation, novel biomarker discovery, and precision medicine approaches for clinical practice.

Indexed as

Brain InjuriesChorioamnionitisPlacentaBrainFemaleHumansInfant, NewbornPregnancyChorioamnionitisConnectivityImmunomodulationMicrostructureNeural-immuneNeural networkPreterm

Identifiers

PMID40947352
PMCPMC12448110

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.