Evidence map›Paper›PMID 40947745›Full record

ArticleNeurodegenerative disease management

Synergistic effects of curcumin-donepezil therapy in a Drosophila Alzheimer's disease model.

Opeyemi B Ogunsuyi, Odunayo O Oluokun, Adedayo O Ademiluyi, Ganiyu Oboh, Rasheedat A Akeeb, Haruna I Umar, Olawande C Olagoke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurodegenerative disease management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Opeyemi B OgunsuyiDepartment of Medical Biochemistry, School of Basic Medical Sciences, The Federal University of Technology, Akure, Nigeria.
Odunayo O OluokunDrosophila Research Lab, Functional Foods and Nutraceuticals Unit, The Federal University of Technology, Akure, Nigeria.
Adedayo O AdemiluyiDrosophila Research Lab, Functional Foods and Nutraceuticals Unit, The Federal University of Technology, Akure, Nigeria.
Ganiyu ObohDrosophila Research Lab, Functional Foods and Nutraceuticals Unit, The Federal University of Technology, Akure, Nigeria.
Rasheedat A AkeebDepartment of Biochemistry, The Federal University of Technology, Akure, Nigeria.
Haruna I UmarDepartment of Biochemistry, The Federal University of Technology, Akure, Nigeria.
Olawande C OlagokeDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite emerging therapeutic options, Alzheimer´s disease (AD) management remains suboptimal due to multimodal pathogenesis. We investigated curcumin-donepezil combination therapy, as curcumin demonstrates antioxidant, anti-inflammatory, and anti-amyloidogenic properties that may complement donepezil's cholinesterase inhibition. RESEARCH DESIGN AND

methodsWe employed the elav-Gal4/UAS-hAPP-BACE-1 Drosophila melanogaster model alongside molecular docking simulation and ADMET prediction to evaluate curcumin-donepezil combination versus monotherapy. Fruit flies received the treatment regimen, and were tested for survival, memory performance, and biochemical markers, including BACE-1 activity and oxidative stress parameters.

resultsCombination therapy significantly improved survival rates and memory performance compared to individual treatment. The combination effectively modulated multiple AD-related pathways, demonstrating reduced BACE-1 activity and decreased oxidative stress markers. Molecular docking confirmed favorable drug interactions, and ADMET profiles supported therapeutic viability.

conclusionsCurcumin-donepezil combination therapy shows promise as a multi-target approach for AD management. However, translation to clinical applications requires validation in higher-order models and human trials.

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsCurcuminDonepezilAnimalsDisease Models, AnimalDrosophila melanogasterDrug SynergismDrug Therapy, CombinationMolecular Docking SimulationOxidative StressCholinesterase InhibitorsCurcuminDonepezilAlzheimer diseasecurcuminDrosophilamolecular dockingRT-qPCRΒ-secretase

Identifiers

PMID40947745
PMCPMC13192091

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.