Evidence map›Paper›PMID 40947826›Full record

ArticleClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2026

Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study.

Cecilia Rosso, Federica Turati, Alberto Maria Saibene, Elvira Verduci, Giuseppe Banderali, Monica Ferraroni, Giovanni Felisati, Carlotta Pipolo

Abstract read
In one paragraph

Article in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cecilia RossoDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0002-2187-0799
Federica TuratiPediatric Clinic, Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-5841-5773
Alberto Maria SaibeneDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0003-1457-6871
Elvira VerduciPediatric Department, ASST Fatebenefratelli Sacco, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0003-2111-3111
Giuseppe BanderaliPediatric Department, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0001-6650-981X
Monica FerraroniPediatric Clinic, Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-4542-4996
Giovanni FelisatiDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0001-6763-4305
Carlotta PipoloDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0001-6628-2117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPaediatric airway diseases such as asthma, allergies, rhinitis, upper respiratory tract infections and acute otitis media are major health challenges for children globally. The prevalence of these conditions has been increasing, impacting children's quality of life, educational attainment and imposing a substantial economic burden.

objectivesThis longitudinal prospective study investigated the prevalence rates and environmental links associated with paediatric airway diseases in the first 3 years of life in 241 newborns, with the goal of contributing to early detection, prevention and management strategies.

methodsStructured questionnaires were administered to parents at birth, 1 year and 3 years of age. Data on socioeconomic factors, pregnancy and delivery characteristics, parental smoking, breastfeeding, childcare attendance and children's health history were collected. Skin prick tests were conducted in year 3 to assess allergic sensitisation.

resultsTwo hundred seven patients completed three-year follow-up. Factors such as having siblings, exclusive breastfeeding and attending kindergarten were associated with increased risks of certain diseases at 1 and 3 years. Smoking exposure appeared protective against wheezing in the first year. Breastfeeding showed mixed results, with protective effects against URTIs at 1 year but a potential risk factor for asthma at 1 year. Kindergarten attendance was associated with increased risks of URTIs and AOM at 3 years but appeared protective against inhalant allergies.

conclusionThe study highlighted the complex interplay of various factors in the development of paediatric airway diseases. Further research is needed to refine our understanding of these factors and their impact on paediatric diseases.

Indexed as

Environmental ExposureRespiratory Tract DiseasesBreast FeedingChild, PreschoolFemaleHumansInfantInfant, NewbornItalyMalePregnancyPrevalenceProspective StudiesRisk FactorsSurveys and Questionnairesacute otitis mediaallergyenvironmentpaediatric ENT diseasesrisk factorsupper respiratory tract infections

Identifiers

PMID40947826
PMCPMC12703668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.