Evidence map›Paper›PMID 40948132›Full record

ArticleCirculation research2025

Functional Analysis of a Homozygous MYBPC3 Null Allele in Human Pediatric Patients.

Jeffrey S Bennett, Patrick T Wood, Katherine L Dominic, Christine S Moravec, Kenneth S Campbell, Julian E Stelzer

Abstract readLetter
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeffrey S BennettDepartment of Pediatric Cardiology (J.S.B.), Cleveland Clinic, OH.ORCID 0000-0002-3665-5661
Patrick T WoodDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH (P.T.W., K.L.D., J.E.S.).ORCID 0000-0002-4226-6507
Katherine L DominicDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH (P.T.W., K.L.D., J.E.S.).ORCID 0000-0002-9359-2871
Christine S MoravecDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute (C.S.M.), Cleveland Clinic, OH.ORCID 0000-0001-7369-1218
Kenneth S CampbellDivision of Cardiovascular Medicine and Department of Physiology, University of Kentucky, Lexington (K.S.C.).ORCID 0000-0001-5615-5958
Julian E StelzerDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH (P.T.W., K.L.D., J.E.S.).ORCID 0000-0002-6870-9054

Funding

Medical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1M
Computer modeling of myosin binding protein C and its effects on cardiac contractionR01HL146676 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Kenneth S Campbell, Julian Stelzer · 2019 to 2026
$4.3M
Functional consequences of FHC mutations in cardiac MyBPCR01HL114770 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2013 to 2023
$4.3M
Novel downstream effectors of protein kinase G in hypertensive diseaseR01HL153236 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2021 to 2024
$2.5M
KUH-TN Training CoreTL1DK132770 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Evi X. Stavrou · 2021 to 2026
$2.5M
KUH-TN Professional Development CoreU2CDK129440 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI MIRELA AURORA DOBRE · 2021 to 2026
$2.0M
Biological Basis of Genetic cMyBP-C CardiomyopathiesR01HL173989 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Kenneth S Campbell, Julian Stelzer · 2024 to 2026
$2.0M
Molecular Basis for cMyBP-C HCM variantsR01HL175803 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI KRISHNA CHINTHALAPUDI, Julian Stelzer · 2025 to 2026
$1.4M
Biological basis of cardiac thick filament regulationR01HL181868 · NHLBI · OHIO STATE UNIVERSITY · PI KRISHNA CHINTHALAPUDI, Julian Stelzer · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL114770NHLBI NIH HHS R01 HL146676NHLBI NIH HHS R01 HL153236NHLBI NIH HHS R01 HL173989NHLBI NIH HHS R01 HL175803NHLBI NIH HHS R01 HL181868NIDDK NIH HHS TL1 DK132770NIDDK NIH HHS U2C DK129440NIGMS NIH HHS T32 GM152319
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiac myosinheart failurehypertrophymutationmyocardium

Identifiers

PMID40948132
PMCPMC12632248

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.