Evidence map›Paper›PMID 40948366›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biosynthesis of H

Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M C Cheung, Kelvin Wai Kwok Yeung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Biosynthesis of HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Congyang MaoDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Wanyu JinDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Yiming XiangDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Yizhou ZhuDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Jun WuShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Xiangmei LiuSchool of Life Science and Health Engineering, Hebei University of Technology, Xiping Avenue 5340, Beichen, Tianjin, 300401, China.
Shuilin WuSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Wei QiaoDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Kenneth M C CheungDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
Kelvin Wai Kwok YeungDepartment of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.ORCID https://orcid.org/0000-0003-0887-088X

Funding

General Research Fund of Hong Kong Research Grant Council 17111322Hong Kong Health and Medical Research Fund 20190422Hong Kong Health and Medical Research Fund 21200592Hong Kong Health and Medical Research Fund 22210832Hong Kong Health and Medical Research Fund 23220752Hong Kong Health and Medical Research Fund 23220952National Key R&D Program of China 2023YFB3810200National Science Fund for Distinguished Youth Scholar 51925104Shenzhen Science and Technology Funding JCYJ20210324120009026Shenzhen Science and Technology Funding JCYJ20210324120012034
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and silver. Herein, it is reported that Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, develop resistance to ROS after six repeated exposures. Notably, ROS minimum inhibitory concentration of Pseudomonas aeruginosa significantly increases to 256-fold after ten passages. The resistance mechanism predominantly originates from the intensified biosynthesis of the highly reductive hydrogen sulfide (H

Indexed as

Drug Resistance, BacterialGram-Negative BacteriaHydrogen SulfideReactive Oxygen SpeciesSiderophoresAnti-Bacterial AgentsMicrobial Sensitivity TestsAnti-Bacterial AgentsHydrogen SulfideReactive Oxygen SpeciesSiderophoresGram‐negative bacteriahydrogen sulfideouter membrane biogenesispyoverdine siderophoresROS resistanceROS scavenging

Identifiers

PMID40948366
PMCPMC12677624

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.