Evidence map›Paper›PMID 40948388›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Decreased RYR2 Cluster Size and Abnormal SR Ca

Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Decreased RYR2 Cluster Size and Abnormal SR CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Jiaxi ShenKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Xiaochen WangKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Hangping FanKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Yaxun SunDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Tingyu GongKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Hangyuan QiuDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Jue WangKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Ziwei PanKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Yanna DangDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Hongkun WangKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Danni ZhouKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Tianyi ZhuZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Hao WangPrenatal Diagnosis Center, Hangzhou Women's Hospital, Hangzhou, 310008, China.
Xianzhen ChenDepartment of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Lizhen XuDepartment of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jun SuKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Fan YangDepartment of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yiquan TangState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Xuguang LiDepartment of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.
Bing YangZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Lenan ZhuangDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Wei WangCardiovascular Research Institute of Jiangxi Province, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China.
Chenyang JiangDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Ping LiangKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.ORCID https://orcid.org/0000-0001-6806-3735

Funding

Key Project of Jiangxi Provincial Natural Science Foundation 20224ACB206004Key Research and Development Program of Zhejiang Province 2019C03022"LingYan" Research and Development Project 2024C03155National Key Research and Development Program of China 2017YFA0103700National Natural Science Foundation of China 81670370National Natural Science Foundation of China 81870175National Natural Science Foundation of China 81922006National Natural Science Foundation of China 81941003National Natural Science Foundation of China 81970269National Natural Science Foundation of China 82360073National Natural Science Foundation of China 82370354National Natural Science Foundation of China 82400372Natural Science Foundation of Zhejiang Province LD21H020001Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0521500Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0521502Outstanding Youth Foundations of Natural Science Foundation of Hebei Province H2017206381
6 · The paper itself

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy featured by life-threatening arrhythmias. While TMEM43 has been identified as an ARVC-associated gene, molecular links between TMEM43 mutations and electrophysiological abnormalities in ARVC remain largely elusive. Here, using induced-pluripotent-stem-cell-derived cardiomyocytes (iPSC-CMs) and knock-in mice as models, it is demonstrated that a novel TMEM43 mutation (TMEM43-P386S) causes Ca

Indexed as

Arrhythmias, CardiacArrhythmogenic Right Ventricular DysplasiaCalciumMembrane ProteinsRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAnimalsDisease Models, AnimalHumansInduced Pluripotent Stem CellsMiceMutationMyocytes, CardiacCalciumMembrane ProteinsRyanodine Receptor Calcium Release ChannelTMEM43 protein, humanarrhythmiaARVCiPSC‐CMslamin B2RYR2TMEM43

Identifiers

PMID40948388
PMCPMC12677635

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.