Evidence map›Paper›PMID 40948552›Full record

ArticleiScience2025

Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules.

Kathryn Fleming, Kate Burley, Fernando Ponce-Garcia, Parsa Akbari, Claire Naveh, Chris Rice, Przemysław Zakrzewski, Willem Gibbs, Sarah Groves, Drinalda Cela and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kathryn FlemingSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Kate BurleySchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Fernando Ponce-GarciaSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Parsa AkbariBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Wort's Causeway, Cambridge, UK.
Claire NavehSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Chris RiceSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Przemysław ZakrzewskiSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Willem GibbsSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Sarah GrovesSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Drinalda CelaThe Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
Venizelos PapayannopoulosThe Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
Christopher J HarbortCellular Microbiology, Max Planck Institute for Infection Biology, Chariteplatz 1, Berlin, Germany.
Andrew MumfordSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Borko AmulicSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are essential immune cells loaded with cytosolic granules that contain potent antimicrobial and immunostimulatory molecules. Alterations of neutrophil granule contents are associated with immunodeficiency and hyperinflammation. Identification of regulators of granule development can aid in understanding of neutrophil-driven pathologies. Here, we perform a systematic prioritization of genetic variants associated with neutrophil cytometric side scatter (SSC), a proxy for granularity, identified in a genome-wide association study (GWAS) of blood parameters in healthy individuals. We show that triangulation of GWAS data with epigenetic and eQTL data identifies previously unknown factors regulating neutrophil granularity. We validate this approach using cellular and animal models to confirm that cyclin dependent kinase 6 (encoded by

Indexed as

Biological sciencesGeneticsImmunologyNatural sciences

Identifiers

PMID40948552
PMCPMC12432455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.