Evidence map›Paper›PMID 40948635›Full record

ArticleFrontiers in neurology2025

Association between the atherogenic index of plasma and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis.

Yan Jiang, Mingzhu Deng, Kangping Song, Zhen Wang, Wei Xu, Tieqiao Feng, Sufen Chen, Can Wan, Xiugui Ma, Fangyi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan Jiang *Department of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China.
Mingzhu Deng *Department of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China.
Kangping SongDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Zhen WangDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Wei XuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Tieqiao FengDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Sufen ChenDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Can WanDepartment of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China.
Xiugui MaDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Fangyi LiDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The atherogenic index of plasma (AIP) and non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) are newly developed markers of lipid and glucose metabolism. Nevertheless, the associations between the AIP or NHHR and early neurological deterioration (END) following thrombolysis in patients with acute ischemic stroke (AIS) remain ambiguous. Methods: 1,323 AIS patients who had intravenous thrombolysis between January 2018 and October 2024 were retrospectively analyzed. An increase in the National Institutes of Health Stroke Scale (NIHSS) score of > 4 within 24 h following thrombolysis was considered post-thrombolysis END. Logistic regression analysis was conducted to investigate the associations between the AIP and NHHR with post-thrombolysis END. Receiver operating characteristic (ROC) analysis was employed to evaluate the AIP and NHHR capacity to differentiate post-thrombolysis END. Results: Of the 1,323 patients who were recruited, 1,125 (85.03%) had non-END and 198 (14.97%) had post-thrombolysis END. A binary logistic regression model demonstrated that the AIP [odds ratio (OR), 1.657; 95% confidence interval (CI) 1.441-1.875, Conclusion: Our study suggests that the AIP and NHHR could be used as prognostic indicators to predict post-thrombolysis END.

Indexed as

acute ischemic strokeatherogenic index of plasmaearly neurological deteriorationlipid metabolismnon-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratiorisk factor

Identifiers

PMID40948635
PMCPMC12422903

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.