Application of hair HPG axis hormone levels before onset in predicting the risk of stroke.

Jiao Yang, Shuhan Li, Xuan Li, Tiantian Wang, Huihua Deng, Yuanyuan Jia, Dianhuai Meng

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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Jiao Yang *Rehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Shuhan Li *Rehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Xuan LiRehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Tiantian WangRehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Huihua DengSchool of Biological Science and Medical Engineering, Southeast University, Nanjing, China.

Yuanyuan JiaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, China.

Dianhuai MengRehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There have been many studies on the relationship between sex hormones and stress, mood, blood pressure, etc., but its impact on the incidence of stroke remains unknown. Objective: To investigate the expression levels of hypothalamic-pituitary-gonadal (HPG) axis related hormones such as testosterone (T) and progesterone (P) in hair before stroke and their effects on the risk of stroke. Methods: 48 patients with stroke were recruited from November 2022 to May 2023 as the observation group and 35 healthy subjects were recruited as the control group. There was no obvious difference in age, gender and BMI between the two groups ( Results: The T and P levels of hair before the onset of stroke in the observation group were significantly lower than those in the control group ( Conclusion: This preliminary report is the first to suggest that HPG axis hormones such as T and P in hair could have predictive value in screening for stroke risk.

Indexed as

hormoneshypothalamic–pituitary-gonadal axisprogesteronestroketestosterone

Identifiers

PMID40948651

DOI10.3389/fneur.2025.1595429

PMCPMC12422911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.