ArticleFrontiers in neurology2025
Effect of electroencephalogram-guided anesthesia on postoperative delirium in older adults after surgery: a systematic review and meta-analysis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Beyond processed depth targets: frontal EEG patterns, brain vulnerability, and postoperative delirium in older adults.Journal of clinical monitoring and computing · 2026Review
- Effect of electroencephalography-guided general anesthesia on postoperative delirium : A meta-analysis of randomized controlled trials.Die Anaesthesiologie · 2026Article
- Article
- Enhancing Anesthetic Depth Assessment via Unsupervised Machine Learning in Processed Electroencephalography Analysis: Novel Methodological Study.JMIR medical informatics · 2026Article
- Precision Sedation for Gastrointestinal Endoscopy in Older Adults: Brain Vulnerability and Recovery.Drug design, development and therapy · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Postoperative delirium is a frequent and severe complication among elderly surgical patients. Electroencephalogram (EEG)-guided anesthesia, which optimizes sedation depth, holds promise for preventing postoperative delirium; however, current research findings remain inconsistent. This meta-analysis incorporates the most recent trials to evaluate the effectiveness of EEG-guided anesthesia in reducing postoperative delirium incidence in older adults. Methods: We conducted a comprehensive literature search of PubMed, the Cochrane Central Register of Controlled Trials, and Embase from their inception to February 1, 2025, to identify eligible studies. This systematic review and meta-analysis aimed to evaluate the effectiveness of electroencephalogram-guided anesthesia in preventing postoperative delirium among elderly surgical patients. Pooled effect estimates for all outcomes were calculated using a random-effects model. The quality and certainty of the evidence were assessed using the GRADE methodology. The primary outcome was the occurrence of postoperative delirium. Results: Of the 3,151 studies screened, 12 were deemed eligible for inclusion, encompassing a total of 7,441 patients, of whom 3,707 received EEG-guided anesthesia. Compared with standard care, EEG-guided anesthesia demonstrated a beneficial effect in reducing postoperative delirium among elderly patients (RR = 0.76, 95% CI: 0.61-0.96), as well as the incidence of postoperative infections (RR = 0.74, 95% CI: 0.58-0.95). Subgroup analyses revealed no significant interaction based on type of surgery ( Conclusion: EEG-guided anesthesia is associated with a reduced incidence of postoperative delirium in elderly surgical patients.
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