ReviewFrontiers in immunology2025
The emerging role of tissue regulatory T cells in tissue repair and regeneration.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Comparison of plasma cytokine expression in adult haematological malignancy patients with bacterial and/or fungal infections.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Review
- The Promise and Challenges of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Periodontal Disease.Pathogens (Basel, Switzerland) · 2026Review
- Regulatory T cells in axial spondyloarthritis.Communications biology · 2026Review
- TNFR-CD3-engineered regulatory T cells attenuate neuroinflammation and neuropathic pain.Immunologic research · 2026Article
- [Chronic skin damage from UV radiation].Dermatologie (Heidelberg, Germany) · 2026Review
- Beyond the alarm: unveiling the multifaceted role of IL-33 in kidney disease.Frontiers in immunology · 2026Review
- Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies.Frontiers in immunology · 2026Review
- Heterogeneity in semen-mediated tolerogenic responses: defining immunological determinants of reproductive compatibility.Human reproduction open · 2026Article
- Targeting the heart-immune axis after myocardial infarction: from inflammation to immunomodulation.Frontiers in cardiovascular medicine · 2026Review
- A stage-based framework to interpret regulatory T cell biology after heart transplantation.Frontiers in cardiovascular medicine · 2026Review
- Bi-directional communication between regulatory T cells and microglia promotes recovery from spinal cord injury.Neuron · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory T cells (Tregs) are a unique subset of T cells vital for maintaining immune balance, preventing autoimmune diseases, and controlling immune responses. First identified in the early 1990s, Tregs are now well recognized for their role in suppressing excessive immune reactions and promoting tolerance to the body's tissues. Among the broader Treg population, Tissue regulatory T cells (Tissue Tregs) are distinct as they do more than suppress immunity; they actively contribute to tissue repair and regeneration. Studies in both mice and humans have highlighted the important role of in aiding tissue repair and maintaining tissue integrity. Recent research reveals that Tregs participate in wound healing and tissue regeneration across various organs, including the heart, liver, kidneys, muscles, lungs, bones, and central nervous system. These discoveries emphasize the wide-ranging and significant influence of Tregs in fostering recovery and healing in different tissues throughout the body. These cells are characterized by their ability to produce a variety of growth factors, cytokines, and signaling molecules that support the repair and regeneration of damaged tissues. In this review, we present an overview of the emerging understanding of Treg-mediated repair processes in damaged tissues and organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.