SynthesisFrontiers in immunology2025
Comorbidities in primary cicatricial alopecia: a systematic review and meta-analysis.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Clinical Insights and Prognostic Factors in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Retrospective Cohort Study.Dermatology (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Primary cicatricial alopecia (PCA) is known to be associated with various comorbidities; however, findings regarding the likelihood of specific comorbidities in PCA patients have been inconsistent. Objective: This study aimed to assess the prevalence and odds of specific comorbidities in patients with PCA compared to controls, and to explore the distribution of comorbidities across various types of PCA. Methods: Electronic searches were conducted using PubMed, Embase, and Scopus from the dates of their inception until July 2024. A total of 116 studies with 33,494 PCA patients that reported data allowing for the calculation of odds ratios (OR) or prevalences of certain comorbidities in PCA patients were included. Results: Systemic lupus erythematosus is more prevalent among patients with lichen planopilaris (LPP) [OR 3.10 (95% confidence interval: 2.24-4.29), prevalence 2%], frontal fibrosing alopecia (FFA) [OR 6.92 (2.73-17.56), prevalence 5%], and central centrifugal cicatricial alopecia (CCCA) [OR 3.13 (1.03-9.49), prevalence 5%]. Hypothyroidism is more prevalent among patients with LPP [OR of 1.73 (1.24-2.42), prevalence 17%] and FFA [OR 1.86 (1.36-2.55), prevalence 19%]. LPP patients are prone to having dermatological diseases such as atopic dermatitis [OR 3.96 (1.14-13.81), prevalence 9%], lichen planus [OR 19.21 (1.47-251.02), prevalence 8%], psoriasis [OR 4.75 (2.04-11.06), prevalence 3%], and rosacea [OR 4.62 (2.96-7.19), prevalence 5%], while FFA patients are prone to having allergic contact dermatitis [OR 3.19 (1.44-7.08), prevalence 41%] and rosacea [OR 2.37 (1.72-3.29), prevalence 16%]. Coronary artery disease is found to be more common in LPP than controls [OR 1.63 (1.43-1.86), prevalence 8%], while dyslipidemia is more common among FFA [OR 1.41 (1.06-1.88), prevalence 20%] and CCCA [OR 4.46 (1.01-19.75), prevalence 54%] than controls, and diabetes mellitus is more prevalent among CCCA than controls [OR 1.67 (1.03-2.69), prevalence 26%]. While skin cancer [OR 2.22 (1.33-3.70), prevalence 2%] and melanoma [OR 4.46 (1.70-11.76), prevalence 1%] were found to be more common in LPP than controls, rheumatoid arthritis [OR 1.65 (1.09-2.51), prevalence 4%] was found to be more common in FFA than controls, and allergic rhinitis [OR 11.77 (1.55-89.24), prevalence 24%] and anxiety [OR 4.69 (1.29-16.98), prevalence 17%] were found to be more common in CCCA than controls. Conclusions: Patients with PCA are at higher risk of developing a wide range of comorbidities. Physicians should remain vigilant and conduct thorough investigations when clinical clues are present. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=564852, identifier CRD42024564852.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.