Evidence map›Paper›PMID 40948812›Full record

ArticleFrontiers in neuroscience2025

A high triglyceride-glucose index correlates with cognitive impairment in Parkinson's disease: a cross-sectional study.

Yongqing Cheng, Shuangfei You, Xin Wang, Yingchao Ge, Lei Li, Taojie Ren, Songjie Chen, Guojun He, Shouru Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongqing Cheng *Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Shuangfei You *Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Xin WangDepartment of Radiology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Yingchao GeDepartment of Neurology, Qidong Hospital Affiliated to Nantong University, Nantong, Jiangsu, China.
Lei LiDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Taojie RenDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Songjie ChenDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Guojun HeDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Shouru XueDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin resistance (IR) is proved be involved in the pathophysiology of Parkinson's disease (PD). As an effective surrogate marker of IR, the correlation between the triglyceride-glucose (TyG) index and PD remains unclear. This cross-sectional study aimed to explore the association between the TyG index and cognitive impairment in PD (PDCI). Methods: Patients with sporadic PD were consecutively enrolled between May 2022 and October 2023. The cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA). The Spearman correlation analysis was used to evaluate the correlation between TyG index and MoCA score, Unified-Parkinson Disease Rating Scale (UPDRS) III and peripheral blood oxidative stress markers, respectively. Logistic regression analysis was performed to explore the correlation between TyG and PDCI and dementia in PD (PDD). Results: A total of 78 patients were enrolled, of whom 50 (64.1%) were diagnosed with PDCI [26 with mild cognitive impairment (MCI) and 24 with PDD]. The TyG index in patients with dementia and MCI were higher than those with normal cognition (9.32 ± 0.43 vs. 8.90 ± 0.47 vs. 8.51 ± 0.46, Conclusion: Elevated TyG levels were associated with an increased likelihood of PDCI in patients with PD.

Indexed as

biomarkercognitive impairment in Parkinson’s diseaseinsulin resistancepredictortriglyceride-glucose index

Identifiers

PMID40948812
PMCPMC12423050

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.