ArticleFrontiers in neuroscience2025
Electroacupuncture treatment can improve cognitive impairment in spontaneously hypertensive rats: a preliminary DTI study.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertension is a significant risk factor for cognitive impairment. Our group's previous rs-fMRI study has found that acupuncture can enhance the functional connectivity of brain regions related to cognitive function, thereby protecting the cognitive function of spontaneously hypertensive rats (SHRs). Methods: This study aimed to reveal the effects of electroacupuncture on the white matter structure in the brain regions of SHRs using the diffusion tensor imaging (DTI) technique. 20 SHRs were divided into the electroacupuncture group (EA) and the model group (SHR), and 10 Wistar-Kyoto rats were established as the normal control group (WKY). Electroacupuncture was applied to Taichong (LR3) and Zusanli (ST36) acupoints for 12 weeks, with treatment every other day. Blood pressure was measured once every 2 weeks, with DTI scans and the Morris water maze (MWM) tests performed at the end of the 12-week electroacupuncture intervention. Results: The results showed that electroacupuncture significantly decreased systolic and diastolic blood pressure and enhanced spatial learning and memory in SHRs. DTI analysis revealed that hypertension led to increased axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) values in brain regions such as the hippocampus, prefrontal cortex, striatum, amygdaloid body, posterior lobe of cerebellum, olfactory bulb, and piriform cortex, indicating white matter microstructural damage. Electroacupuncture improved these injuries, especially significantly improving the integrity of the hippocampal white matter structure. Correlation analysis showed that hippocampal white matter structure parameters were significantly correlated with behavioral manifestations of MWM. Conclusion: Therefore, we speculate that electroacupuncture can alleviate white matter damage in the hippocampus, prefrontal cortex, striatum, and other brain regions, thereby preventing cognitive impairment in SHRs, which may be one of the reasons for the efficacy of electroacupuncture.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.